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Titolo:
Study on the charge-transfer reaction between 7,7,8,8-tetracyanoquinodimethane and drugs
Autore:
Zhao, FL; Xu, BZ; Zhang, ZQ; Tong, SY;
Indirizzi:
Peking Univ, Dept Chem, Beijing 100871, Peoples R China Peking Univ Beijing Peoples R China 100871 ijing 100871, Peoples R China
Titolo Testata:
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
fascicolo: 2, volume: 21, anno: 1999,
pagine: 355 - 360
SICI:
0731-7085(199911)21:2<355:SOTCRB>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPECTROPHOTOMETRIC DETERMINATION; PI-ACCEPTORS; UTILITY;
Keywords:
charge transfer reaction; spectrophotometry; cinnarizine; analgin; norfloxacin; 7,7,8,8-tetracyanoquinodimethane (TCNQ);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Zhao, FL Peking Univ, Dept Chem, Beijing 100871, Peoples R China Peking Univ Beijing Peoples R China 100871 871, Peoples R China
Citazione:
F.L. Zhao et al., "Study on the charge-transfer reaction between 7,7,8,8-tetracyanoquinodimethane and drugs", J PHARM B, 21(2), 1999, pp. 355-360

Abstract

The charge-transfer (CT) reaction between 7,7,8,8-tetracyanoquinodimethane(TCNQ) as a x-electron acceptor and cinnarizine, analgin, norfloxacin as electron donors have been studied by spectrophotometric method. The charge transfer complexes between TCNQ and these drugs have stable blue color, therefore a simple, rapid, accurate and sensitive method for determination of these drugs has been developed. The optimization of the experimental conditions is described. Beer's law is obeyed in the ranges 2-18, 2-18 and 4-32 mug/ml for cinnarizine, analgin and norfloxacin, respectively. The apparent molar absorptivity of CT complexes at 743 nm is 1.58 x 10(4), 1.71 x 10(4) and 8.91 x 10(3) l/mol per cm, respectively. The composition of all these CT complexes are found to be 1:1 by different methods. The relative SDs are less than 3% (n = 10). The proposed method has been applied to the determination of these drugs in their each pharmaceutical dosage forms with satisfactory results. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 14/11/18 alle ore 04:15:57