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Titolo:
Primary motor cortex involvement in Alzheimer disease
Autore:
Suva, D; Favre, I; Kraftsik, R; Esteban, M; Lobrinus, A; Miklossy, J;
Indirizzi:
CHU Vaudois, Inst Pathol, Div Neuropathol, CH-1011 Lausanne, Switzerland CHU Vaudois Lausanne Switzerland CH-1011 , CH-1011 Lausanne, Switzerland Univ Lausanne, Inst Biol Cellulaire & Morphol, Lausanne, Switzerland Univ Lausanne Lausanne Switzerland ire & Morphol, Lausanne, Switzerland
Titolo Testata:
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
fascicolo: 11, volume: 58, anno: 1999,
pagine: 1125 - 1134
SICI:
0022-3069(199911)58:11<1125:PMCIIA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROFIBRILLARY TANGLES; QUANTITATIVE-ANALYSIS; NEOCORTEX; DEMENTIA; DEGENERATION; DIAGNOSIS;
Keywords:
Alzheimer disease; associative cortex; neurofibrillary tangle; primary motor cortex; primary sensory cortex; pyramidal signs; senile plaques;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Suva, D CHU Vaudois, Inst Pathol, Div Neuropathol, CH-1011 Lausanne, Switzerland CHU Vaudois Lausanne Switzerland CH-1011 1 Lausanne, Switzerland
Citazione:
D. Suva et al., "Primary motor cortex involvement in Alzheimer disease", J NE EXP NE, 58(11), 1999, pp. 1125-1134

Abstract

In Alzheimer disease (AD) the involvement of entorhinal cortex, hippocampus, and associative cortical areas is well established. Regarding the involvement of the primary motor cortex the reported data are contradictory. In order to determine whether the primary motor cortex is involved in AD, the brains of 29 autopsy cases were studied, including, 17 cases with severe cortical AD-type changes with definite diagnoses of AD 7 age-matched cases with discrete to moderate cortical AD-type changes, and 5 control cases without any AD-type cortical changes. Morphometric analysis of the cortical surface occupied by senile plaques (SPs) on beta-amyloid-immunostained sections and quantitative analysis of neurofibrillary tangles (NFTs) on Gallyas-stained sections was performed in 5 different cortical areas including the primary motor cortex. The percentage of cortical surface occupied by SPs was similar in all cortical areas, without significant difference and corresponded to 16.7% in entorhinal cortex, 21.3% in frontal associative, 16% in parietal associative, and 15.8% in primary motor cortex. The number of NFTs in the entorhinal cortex was significantly higher (41 per 0.4 mm(2)), compared with those in other cortical areas (20.5 in frontal, 17.9 in parietal and 11.5 in the primary motor cortex). Our findings indicate that the primary motel cortex is significantly involved in AD and suggest the appearance of motor dysfunction in late and terminal stages of the disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 09:19:11