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Titolo:
Identification of a mammalian homologue of the fungal Tom70 mitochondrial precursor protein import receptor as a thyroid hormone-regulated gene in specific brain regions
Autore:
Alvarez-Dolado, M; Gonzalez-Moreno, M; Valencia, A; Zenke, M; Bernal, J; Munoz, A;
Indirizzi:
Univ Autonoma Madrid, Inst Invest Biomed Alberto Sols, CSIC, E-28029 Madrid, Spain Univ Autonoma Madrid Madrid Spain E-28029 s, CSIC, E-28029 Madrid, Spain CSIC, Ctr Nacl Biotecnol, Cantoblanco, Spain CSIC Cantoblanco SpainCSIC, Ctr Nacl Biotecnol, Cantoblanco, Spain INTA, Ctr Astrobiol, Madrid, Spain INTA Madrid SpainINTA, Ctr Astrobiol, Madrid, Spain Max Delbruck Ctr Mol Med, Berlin, Germany Max Delbruck Ctr Mol Med Berlin Germany ck Ctr Mol Med, Berlin, Germany
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 6, volume: 73, anno: 1999,
pagine: 2240 - 2249
SICI:
0022-3042(199912)73:6<2240:IOAMHO>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARBITRARILY PRIMED PCR; CYTOCHROME-C-OXIDASE; RAT-BRAIN; MESSENGER-RNA; DIFFERENTIAL DISPLAY; EXPRESSION; MEMBRANE; LIVER; HYPOTHYROIDISM; CLONING;
Keywords:
thyroid hormone; KIAA0719 gene; mitochondrial protein import receptor; Tom70; striatum; differential display;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Munoz, A Univ Autonoma Madrid, Inst Invest Biomed Alberto Sols, CSIC, Arturo Duperier 4, E-28029 Madrid, Spain Univ Autonoma Madrid Arturo Duperier 4Madrid Spain E-28029 pain
Citazione:
M. Alvarez-Dolado et al., "Identification of a mammalian homologue of the fungal Tom70 mitochondrial precursor protein import receptor as a thyroid hormone-regulated gene in specific brain regions", J NEUROCHEM, 73(6), 1999, pp. 2240-2249

Abstract

Thyroid hormone is an important regulator of mammalian brain maturation, By differential display PGR, we isolated a cDNA clone (S2) that is specifically upregulated in the striatum of neonatal hypothyroid rats, S2 was identified as KIAA0719, the first human gene distantly homologous to the fungal Tom70, which encodes a member of the translocase mitochondrial outer membrane complex involved in the import of preproteins into the mitochondria, By northern and in situ hybridization studies, KIAA0719 was found to be up-regulated in the striatum, nucleus accumbens, and discrete cortical layers of 15-day-old hypothyroid rats, In contrast, lower expression was found in the olfactory tubercle, whereas no differences were detected in other brain regions. Significantly, treatment of hypothyroid animals with single injections of thyroxine restored the normal levels of KIAA0719 expression. Moreover,treatment of control animals with thyroxine led to a reduced expression, demonstrating a negative hormonal regulation in vivo. Thus, KIAA0719 gene expression is regulated by thyroid hormone in the neonatal vat brain in a region-specific fashion. Given the role of the homologous Tom70 gene, the alteration of KIAA0719 expression may contribute to the changes in mitochondrial morphology and physiology caused by hypothyroidism in the developing rat brain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 08:13:30