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Titolo:
Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction
Autore:
Bosselut, R; Zhang, WG; Ashe, JM; Kopacz, JL; Samelson, LE; Singer, A;
Indirizzi:
NCI, Expt Immunol Branch, NIH, Bethesda, MD 20892 USA NCI Bethesda MD USA20892 xpt Immunol Branch, NIH, Bethesda, MD 20892 USA NCI, Lab Cellular & Mol Biol, NIH, Bethesda, MD 20892 USA NCI Bethesda MDUSA 20892 ellular & Mol Biol, NIH, Bethesda, MD 20892 USA
Titolo Testata:
JOURNAL OF EXPERIMENTAL MEDICINE
fascicolo: 10, volume: 190, anno: 1999,
pagine: 1517 - 1525
SICI:
0022-1007(19991115)190:10<1517:AOTAML>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-TYROSINE KINASE; IMMATURE CD4+CD8+ THYMOCYTES; CYTOPLASMIC DOMAINS; ACTIVATION; PHOSPHORYLATION; P56LCK; ZAP-70; CHAIN; TCR; EXPRESSION;
Keywords:
T cell receptor; development; signaling; thymus; phosphorylation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Singer, A NCI, Expt Immunol Branch, NIH, Bldg 10,Rm 4B36, Bethesda, MD 20892 USA NCI Bldg 10,Rm 4B36 Bethesda MD USA 20892 Bethesda, MD 20892 USA
Citazione:
R. Bosselut et al., "Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction", J EXP MED, 190(10), 1999, pp. 1517-1525

Abstract

Linker for activation of T cells (LAT) is an adaptor protein whose tyrosine phosphorylation is critical for transduction of the T cell receptor (TCR)signal. LAT phosphorylation is accomplished by the protein tyrosine kinaseZAP-70, but it is not at all clear how LAT (which is not associated with the TCR) encounters ZAP-70 (which is bound to the TCR). Here we show that LAT associates with surface CD4 and CD8 coreceptors and that its association is promoted by the same coreceptor cysteine motif that mediates Lck binding. In Get, LAT competes with Lck for binding to individual coreceptor molecules but differs from Lck in its preferential association with CD8 rather than CD4 ill CD4(+)CD8(+) thymocytes. Importantly, as a consequence of LAT association with surface coreceptors, coengagement of the TCR with surface coreceptors induces LAT phosphorylation and the specific recruitment of downstream signaling mediators to coreceptor-associated LAT molecules. These results point to a new function for CD-F and CD8 coreceptors in TCR signal transduction, namely to promote LAT phosphorylation by ZAP-70 by recruiting LAT to major histocompatibility complex-engaged TCR complexes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/11/20 alle ore 21:44:26