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Titolo:
Identification and molecular characterization of NKp30, a novel triggeringreceptor involved in natural cytotoxicity mediated by human natural killercells
Autore:
Pende, D; Parolini, S; Pessino, A; Sivori, S; Augugliaro, R; Morelli, L; Marcenaro, E; Accame, L; Malaspina, A; Biassoni, R; Bottino, C; Moretta, L; Moretta, A;
Indirizzi:
Ist Nazl Ric Canc, I-16132 Genoa, Italy Ist Nazl Ric Canc Genoa Italy I-16132 azl Ric Canc, I-16132 Genoa, Italy Univ Brescia, Dipartimento Sci Biomed & Biotecnol, I-25100 Brescia, Italy Univ Brescia Brescia Italy I-25100 d & Biotecnol, I-25100 Brescia, Italy Univ Genoa, Dipartimento Med Sperimentale, I-16132 Genoa, Italy Univ Genoa Genoa Italy I-16132 to Med Sperimentale, I-16132 Genoa, Italy
Titolo Testata:
JOURNAL OF EXPERIMENTAL MEDICINE
fascicolo: 10, volume: 190, anno: 1999,
pagine: 1505 - 1516
SICI:
0022-1007(19991115)190:10<1505:IAMCON>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HLA CLASS-I; INHIBITORY RECEPTOR; NK CELLS; MONOCLONAL-ANTIBODIES; SURFACE-MOLECULE; LYMPHOCYTES-T; MHC; CLONING; RECOGNITION; EXPRESSION;
Keywords:
natural killer cells; triggering receptor; natural cytotoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Moretta, L Ctr Biotecnol Avanzate, Lab Immunopatol, Lgo R Benzi 10, I-16132 Genoa, Italy Ctr Biotecnol Avanzate Lgo R Benzi 10 Genoa Italy I-16132 taly
Citazione:
D. Pende et al., "Identification and molecular characterization of NKp30, a novel triggeringreceptor involved in natural cytotoxicity mediated by human natural killercells", J EXP MED, 190(10), 1999, pp. 1505-1516

Abstract

Two major receptors involved in human natural cytotoxicity, NKp46 and NKp44, have recently been identified. However, experimental evidence suggested the existence of additional such receptor(s). Ira this study, by the generation of monoclonal antibodies (mAbs), we identified NKp30, a novel 30-kD triggering receptor selectively expressed by all resting and activated human natural killer (NK) cells. Although mAb-mediated cross-linking of NKp30 induces strong NK cell activation, mAb-mediated masking inhibits the NK cytotoxicity against normal or tumor target cells. NKp30 cooperates with NKp46 and/or NKp44 in the induction of NK-mediated cytotoxicity against the majority of target cells, whereas it represents the major triggering receptor in die killing of certain tumors. This novel receptor is associated with CD3 zeta chains that become tyrosine phosphorylated upon sodium pervanadate treatment of NK cells. Molecular cloning of NKp30 cDNA revealed a member of the immunoglobulin superfamily, characterized by a single V-type domain and a charged residue in the transmembrane portion. Moreover, we show that NKp30 is encoded by the previously identified 1C7 gene, for which the function andthe cellular distribution of the putative product were not identified in previous studies.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 21:23:00