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Titolo:
In vitro and in vivo activation of polymorphonuclear leukocytes in response to particulate debris
Autore:
Chen, FS; Scher, DM; Clancy, RM; Vera-Yu, A; Di Cesare, PE;
Indirizzi:
Hosp Joint Dis Orthopaed Inst, Dept Orthopaed Surg, Musculoskeletal Res Ctr, New York, NY 10003 USA Hosp Joint Dis Orthopaed Inst New York NY USA 10003 ew York, NY 10003 USA Hosp Joint Dis Orthopaed Inst, Dept Rheumatol, New York, NY 10003 USA HospJoint Dis Orthopaed Inst New York NY USA 10003 ew York, NY 10003 USA
Titolo Testata:
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
fascicolo: 6, volume: 48, anno: 1999,
pagine: 904 - 912
SICI:
0021-9304(199912)48:6<904:IVAIVA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOTAL HIP-ARTHROPLASTY; INFLAMMATORY RESPONSE; BONE-RESORPTION; IN-VIVO; PERIPROSTHETIC OSTEOLYSIS; TISSUE-CULTURE; WEAR DEBRIS; PARTICLES; TITANIUM; POLYETHYLENE;
Keywords:
particulate; wear debris; arthroplasty; aseptic loosening; inflammation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Di Cesare, PE Hosp Joint Dis Orthopaed Inst, Dept Orthopaed Surg, Musculoskeletal Res Ctr, 301 E 17th St, New York, NY 10003 USA Hosp Joint Dis Orthopaed Inst 301 E 17th St New York NY USA 10003
Citazione:
F.S. Chen et al., "In vitro and in vivo activation of polymorphonuclear leukocytes in response to particulate debris", J BIOMED MR, 48(6), 1999, pp. 904-912

Abstract

The host inflammatory response to particulate wear debris has been implicated as a principal cause of osteolysis and aseptic loosening following total joint arthroplasty. While it has long been assumed that this inflammatoryresponse is mediated solely by a chronic process, there has been evidence to suggest that an acute response to particulate debris may be important ininitiating the chronic response. We studied the in vitro and in vivo acuteinflammatory responses mediated by polymorphonuclear leukocytes (PMNs) to both retrieved particulate from a catastrophically failed uncemented metal-backed acetabular component and to commercially pure particulate (polyethylene, cobalt-chrome, and titanium). Isolated, nonactivated human PMNs in vitro exhibited both a dose- and time-dependent degranulation response to opsonized particulate debris, as evidenced by release of both specific (increased lysozyme activity) and azurophilic (increased beta-glucuronidase activity) granule contents. In the rat subcutaneous pouch model in Fire, PMNs wererecruited within 3-6 h after exposure to particulate debris and were notedto phagocytize particulate and subsequently degranulate, as evidenced by increased beta-glucuronidase and PMN-specific myeloperoxidase (azurophilic granule enzymes) activities. This response peaked within the first 6 h and gradually declined by 24 h, The results of this study demonstrate the presence of an acute inflammatory response mediated by PMNs both in vitro and in vivo to particulate debris, which may be important in the sequence of events that lead to the macrophage-dominated chronic inflammatory process culminating in osteolysis and aseptic loosening of total joint arthroplasties, (C) 1999 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:14:12