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Titolo:
Antioxidant transport modulates peripheral airway reactivity and inflammation during ozone exposure
Autore:
Freed, AN; Cueto, R; Pryor, WA;
Indirizzi:
Johns Hopkins Med Inst, Dept Environm Hlth Sci, Baltimore, MD 21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 ci, Baltimore, MD 21205 USA Louisiana State Univ, Inst Biodynam, Baton Rouge, LA 70803 USA Louisiana State Univ Baton Rouge LA USA 70803 , Baton Rouge, LA 70803 USA
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 5, volume: 87, anno: 1999,
pagine: 1595 - 1603
SICI:
8750-7587(199911)87:5<1595:ATMPAR>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
BRONCHOALVEOLAR LAVAGE; PULMONARY-FUNCTION; NEUTROPHIL INFLUX; HEALTHY-SUBJECTS; CYTOPLASMIC PH; ASCORBIC-ACID; IN-VITRO; DOGS; LUNG; HYPERRESPONSIVENESS;
Keywords:
airway hyperreactivity; anion transport; bronchoalveolar lavage; dog; lung; neutrophils; transepithelial potential difference; urate; vitamin C;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Freed, AN Johns Hopkins Univ, Sch Publ Hlth, Dept Environm Hlth Sci, 615 NWolfe St,Baltimore, MD 21205 USA Johns Hopkins Univ 615 N Wolfe St Baltimore MD USA 21205 205 USA
Citazione:
A.N. Freed et al., "Antioxidant transport modulates peripheral airway reactivity and inflammation during ozone exposure", J APP PHYSL, 87(5), 1999, pp. 1595-1603

Abstract

We examined the effects of ozone (O-3) and endogenous antioxidant transport on canine peripheral airway function, central airway function, epithelialintegrity, and inflammation Dogs were either untreated or pretreated with probenecid tan anion-transport inhibitor) and exposed for 6 h to 0.2 parts/million O-3 Peripheral airway resistance (Rpa) and reactivity (Delta Rpa) were monitored in three sublobar locations before and after exposure to either air or O-3. Pulmonary resistance and transepithelial potential difference in trachea and bronchus were also recorded. Bronchoalveolar lavage fluid (BALF) was collected before, during, and after exposure. O-3 increased Rpa and Delta Rpa only in probenecid-treated dogs and in a location-dependent fashion. Pulmonary resistance and potential difference in bronchus increasedafter O-3 exposure regardless of treatment. O-3 markedly increased BALF neutrophils only in untreated dogs. With the exception of hexanal, O-3 did not alter any BALF constituent examined. Probenecid reduced BALF ascorbate, BALF protein, and plasma urate. We conclude that 1) a 6-h exposure to 0.2 parts/million O-3 represents a subthreshold stimulus in relation to its effects an peripheral airway function in dogs, 2) antioxidant transport contributes to the maintenance of normal airway tone and reactivity under conditions of oxidant stress, 3) O-3-induced changes in Rpa and Delta Rpa are dependent on location, and 4) peripheral airway hyperreactivity and inflammation reflect independent responses to O-3 exposure. Finally, although anion transport mitigates the effect of O-3 On peripheral airway function, it contributes to the development of airway inflammation and may represent a possibletarget for anti-inflammatory prevention or therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 17:39:45