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Titolo:
Inhibitory effect of natural and environmental estrogens on thymic hormoneproduction in thymus epithelial cell culture
Autore:
Sakabe, K; Okuma, M; Karaki, S; Matsuura, S; Yoshida, T; Aikawa, H; Izumi, S; Kayama, F;
Indirizzi:
Tokai Univ, Sch Med, Dept Morphol, Isehara, Kanagawa 2591193, Japan Tokai Univ Isehara Kanagawa Japan 2591193 sehara, Kanagawa 2591193, Japan Tokai Univ, Sch Med, Dept Environm Hlth, Isehara, Kanagawa 2591193, Japan Tokai Univ Isehara Kanagawa Japan 2591193 sehara, Kanagawa 2591193, Japan Tokai Univ, Sch Med, Dept Obstet & Gynecol, Isehara, Kanagawa 2591193, Japan Tokai Univ Isehara Kanagawa Japan 2591193 sehara, Kanagawa 2591193, Japan Jichi Med Sch, Dept Environm Hlth, Kawachi, Tochigi 3291100, Japan Jichi Med Sch Kawachi Tochigi Japan 3291100 wachi, Tochigi 3291100, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY
fascicolo: 12, volume: 21, anno: 1999,
pagine: 861 - 868
SICI:
0192-0561(199912)21:12<861:IEONAE>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEX STEROID-HORMONES; PROGESTERONE RECEPTORS; RAT THYMUS; SECRETION; DIFFERENTIATION; LOCALIZATION; LYMPHOCYTES; EXPRESSION; PREGNANCY; LINE;
Keywords:
estrogen; environmental estrogen; endocrine disrupters; thymus epithelial cells; thymic hormone production;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Sakabe, K Tokai Univ, Sch Med, Dept Morphol, Isehara, Kanagawa 2591193, Japan Tokai Univ Isehara Kanagawa Japan 2591193 nagawa 2591193, Japan
Citazione:
K. Sakabe et al., "Inhibitory effect of natural and environmental estrogens on thymic hormoneproduction in thymus epithelial cell culture", INT J IMMUN, 21(12), 1999, pp. 861-868

Abstract

The present study was carried out to assess the direct effect of natural estrogen and environmental estrogens on thymus epithelial cell (TEC) production/secretion of the thymic hormone thymosin-alpha 1 by using the techniqueof quantitative high-performance liquid chromatography. The presence of estrogen receptors in the TECs was also investigated. Murine TECs were cultured in the experimental DMEM medium containing various concentrations of natural or environmental estrogens, which was followed by determining the production of thymosin-alpha 1. The production of thymosin-alpha 1 by TECs was significantly inhibited by increasing concentrations of 17 beta-estradiol (natural estrogen) over 3 x 10(-11) M, genistein (phytoestrogen) over 3 x 10(-9) M, coumestrol (phytoestrogen) over 3 x 10-9 M, alpha-zearalanol (livestock anabolic) over 3 x 10(-7) and bisphenol-A (plastic) over 3 x 10(-6) M. Small amounts of estrogen receptor were present in the TECs. The above results clearly indicate that natural and environmental estrogens directly modulate TECs to produce thymic hormone probably through an estrogen receptor mechanism. Furthermore, our finding may be useful for evaluating biologicaleffects of chemicals with estrogenic activity. (C) 1999 International Society for Immunopharmacology. Published by Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 11:16:10