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Titolo:
Angiotensin II stimulates gene expression of cardiac insulin-like growth factor I and its receptor through effects on blood pressure and food intake
Autore:
Brink, M; Chrast, J; Price, SR; Mitch, WE; Delafontaine, P;
Indirizzi:
Univ Hosp, Div Cardiol, Geneva, Switzerland Univ Hosp Geneva Switzerland niv Hosp, Div Cardiol, Geneva, Switzerland Emory Univ, Sch Med, Div Renal, Atlanta, GA 30322 USA Emory Univ Atlanta GA USA 30322 Sch Med, Div Renal, Atlanta, GA 30322 USA
Titolo Testata:
HYPERTENSION
fascicolo: 5, volume: 34, anno: 1999,
pagine: 1053 - 1059
SICI:
0194-911X(199911)34:5<1053:AISGEO>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC HEART-FAILURE; LEFT-VENTRICULAR HYPERTROPHY; ADULT-RAT HEART; DILATED CARDIOMYOPATHY; MESSENGER-RNA; HORMONE; INDUCTION; INCREASES; HYPERTENSION; INHIBITION;
Keywords:
hypertrophy, cardiac; heart failure; growth substances; angiotensin II; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Brink, M Univ Geneva, Dept Med, Div Cardiol, Ave Roseraie 64, CH-1211 Geneva, Switzerland Univ Geneva Ave Roseraie 64 Geneva Switzerland CH-1211 itzerland
Citazione:
M. Brink et al., "Angiotensin II stimulates gene expression of cardiac insulin-like growth factor I and its receptor through effects on blood pressure and food intake", HYPERTENSIO, 34(5), 1999, pp. 1053-1059

Abstract

Angiotensin II (Ang II) is known to act as a growth factor and may be involved in cardiac remodeling. We have shown that insulin-like growth factor-I(IGF-I) is an autocrine mediator of growth responses to Ang II in vascularsmooth muscle cells in vitro, and we hypothesized that IGF-I also serves as an important modulator of cardiovascular growth in vivo. To study the effect of Ang II on cardiac IGF-I, we infused rats for 3, 7, or 14 days with Ang II through osmotic minipumps. After 7 days, left ventricular mass normalized for body weight was increased by 20% (P<0.01) in Ang II rats compared with pair-fed control rats that were given a restricted amount of food identical to that eaten by the anorexic, Ang II-infused rats. Ang II increased left ventricular IGF-I mRNA levels by 1.5- to 1.8-fold compared with ad libitum-fed or pair-fed control rats (P<0.05). Cardiac IGF-I protein was increased correspondingly and was localized on the cardiomyocytes. Treatment with hydralazine abolished the induction of IGF-I mRNA, which indicates that Ang II induces cardiac IGF-I mRNA expression through a pressor-mediated mechanism. IGF-I receptor (IGF-IR) mRNA was induced 2.1-fold in Ang II rats compared with ad libitum-fed rats (P<0.01). However, this increase was also observed in pair-fed controls and is thus due to the anorexigenic effect of Ang II. We have recently shown that circulating IGF-I levels are reduced in response to Ang II infusion. Elevation of IGF-I levels by coinfusion of IGF-I and Ang II significantly increased left ventricular index by 16% compared with rats infused with Ang II alone (P<0.05). In conclusion, autocrine upregulation of cardiac IGF-I and IGF-IR mRNA by Ang II occurs through hemodynamic and nonhemodynamic mechanisms, respectively, and may modulate cardiacstructural changes that occur in hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:59:25