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Titolo:
Expression of aromatase cytochrome P450 in eutopic endometrium and its application as a diagnostic test for endometriosis
Autore:
Kitawaki, J; Kusuki, I; Koshiba, H; Tsukamoto, K; Honjo, H;
Indirizzi:
Kyoto Prefectural Univ Med, Dept Gynecol & Obstet, Kamigyo Ku, Kyoto 6028566, Japan Kyoto Prefectural Univ Med Kyoto Japan 6028566 Ku, Kyoto 6028566, Japan
Titolo Testata:
GYNECOLOGIC AND OBSTETRIC INVESTIGATION
, volume: 48, anno: 1999, supplemento:, 1
pagine: 21 - 26
SICI:
0378-7346(1999)48:<21:EOACPI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN UTERINE LEIOMYOMA; STROMAL CELLS; NEOPLASTIC ENDOMETRIUM; ADENOMYOTIC TISSUES; ESTROGEN SYNTHESIS; ANDROSTENEDIONE; GLANDS; GENE;
Keywords:
endometriosis; infertility; aromatase cytochrome; P450; estrogen; endometrial biopsy; diagnostic test immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Kitawaki, J Kyoto Prefectural Univ Med, Dept Gynecol & Obstet, Kamigyo Ku,465 Kajii Cho, Kyoto 6028566, Japan Kyoto Prefectural Univ Med 465 Kajii Cho Kyoto Japan 6028566
Citazione:
J. Kitawaki et al., "Expression of aromatase cytochrome P450 in eutopic endometrium and its application as a diagnostic test for endometriosis", GYNECOL OBS, 48, 1999, pp. 21-26

Abstract

Endometriotic implants, like other estrogen-dependent tumors, contain bothestrogen receptors and aromatase cytochrome P450 (P450arom), suggesting that at a local level, endometriotic implants produce estrogens, which may beinvolved in tissue growth through interaction with the estrogen receptors. P450arom is also expressed in the eutopic endometria of patients with endometriosis, adenomyosis, and/or leiomyomas, whereas neither P450arom proteinnor mRNA is expressed in the eutopic endometria of normal menstruating women with cervical carcinoma in situ yet showing no other gynecological disease (disease-free). Examination of P450arom expression in endometrial biopsyspecimens enables the physician to discriminate between the presence and absence of endometriosis, and may be used as an initial screening at outpatient infertility clinics. Copyright (C) 1999 S. Karger AG. Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 01:49:37