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Titolo:
Cell proliferation after lesions in the cerebellum of adult teleost fish: Time course, origin, and type of new cells produced
Autore:
Zupanc, GKH; Ott, R;
Indirizzi:
Univ Manchester, Sch Biol Sci, Manchester M13 9PT, Lancs, England Univ Manchester Manchester Lancs England M13 9PT M13 9PT, Lancs, England Max Planck Inst Entwicklungsbiol, Abt Phys Biol, D-72076 Tubingen, GermanyMax Planck Inst Entwicklungsbiol Tubingen Germany D-72076 ingen, Germany
Titolo Testata:
EXPERIMENTAL NEUROLOGY
fascicolo: 1, volume: 160, anno: 1999,
pagine: 78 - 87
SICI:
0014-4886(199911)160:1<78:CPALIT>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL POSTERIOR/PREPACEMAKER NUCLEUS; CENTRAL-NERVOUS-SYSTEM; APTERONOTUS-LEPTORHYNCHUS; GYMNOTIFORM FISH; POSTEMBRYONIC DEVELOPMENT; DNA-REPLICATION; BRAIN; MIGRATION; APOPTOSIS; BROMODEOXYURIDINE;
Keywords:
neuronal regeneration; stab wounds; postnatal neurogenesis; 5-bromo-2 '-deoxyuridine; gymnotiform fish; Apteronotus leptorhynchus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Zupanc, GKH Univ Manchester, Sch Biol Sci, 3-614 Stopford Bldg,Oxford Rd, Manchester M13 9PT, Lancs, England Univ Manchester 3-614 Stopford Bldg,Oxford Rd Manchester Lancs England M13 9PT
Citazione:
G.K.H. Zupanc e R. Ott, "Cell proliferation after lesions in the cerebellum of adult teleost fish: Time course, origin, and type of new cells produced", EXP NEUROL, 160(1), 1999, pp. 78-87

Abstract

In contrast to mammals, fish exhibit an enormous capacity Co replace damaged neurons following injuries to the adult central nervous system. As the mechanisms controlling this so-called neuronal regeneration are unknown, we have, in the present study, examined the role of cell proliferation in thisprocess. Lesions were applied to one subdivision of the cerebellum, the corpus cerebelli, in the teleost fish Apteronotus leptorhynchus. Proliferative activity was monitored through incorporation of the thymidine analogue 5-bromo-2'-deoxyuridine into replicating DNA. Cerebellar lesions induce high proliferative activity especially in areas in close vicinity to the injury,although the number of cells produced is also increased in other regions of the corpus cerebelli. Many of the cells generated in these areas become, after migration, specifically incorporated at the site of the lesion, The vast majority of them is dividing between 1 and 10 days following the lesion, with the maximum proliferative activity occurring at 5 days. Remarkably, also cells dividing 2 days prior to applying a lesion participate, at a significant number; in the regenerative process. Combination of 5-bromo-2'-deoxyuridine labeling with retrograde tract-tracing techniques demonstrated that at least some of the new cells that replace damaged neurons are cerebellar granule cells. This ability to generate new neurons, together with the previously described occurrence of apoptosis to remove damaged cells, is likely to form the basis for the enormous capacity of teleost fish to perform neuronal regeneration. (C) 1999 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 06:37:40