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Titolo:
Melatonin reduces lipid peroxidation and tissue edema in cerulein-induced acute pancreatitis in rats
Autore:
Qi, WB; Tan, DX; Reiter, RJ; Kim, SJ; Manchester, LC; Cabrera, J; Sainz, RM; Mayo, JC;
Indirizzi:
Univ Texas, Hlth Sci Ctr, Dept Cellular & Struct Biol, San Antonio, TX 78284 USA Univ Texas San Antonio TX USA 78284 truct Biol, San Antonio, TX 78284 USA
Titolo Testata:
DIGESTIVE DISEASES AND SCIENCES
fascicolo: 11, volume: 44, anno: 1999,
pagine: 2257 - 2262
SICI:
0163-2116(199911)44:11<2257:MRLPAT>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICROSOMAL MEMBRANE FLUIDITY; FREE-RADICALS; ISCHEMIA-REPERFUSION; SUPEROXIDE-DISMUTASE; ANTIOXIDANT ENZYMES; GENE-EXPRESSION; OXYGEN RADICALS; MODELS; PATHOGENESIS; SCAVENGER;
Keywords:
oxygen free radicals; lipid peroxidation; cerulein; pancreatitis; melatonin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Reiter, RJ Univ Texas, Hlth Sci Ctr, Dept Cellular & Struct Biol, 7703 Floyd Curl Dr,San Antonio, TX 78284 USA Univ Texas 7703 Floyd Curl Dr San Antonio TX USA 78284 8284 USA
Citazione:
W.B. Qi et al., "Melatonin reduces lipid peroxidation and tissue edema in cerulein-induced acute pancreatitis in rats", DIG DIS SCI, 44(11), 1999, pp. 2257-2262

Abstract

Since oxygen free radicals and lipid peroxidation have been implicated in the pathogenesis of an early stage of acute pancreatitis, we examined whether melatonin, a recently discovered free-radical scavenger, could attenuatepancreatic injury in Sprague-Dawley rats with cerulein-induced pancreatitis. Acute pancreatitis was induced by four intraperitoneal injections of cerulein (50 mu g/kg body wt) given at l-hr intervals. Thirty minutes after the last cerulein injection, the rats were killed and the degree of pancreatic edema, the level of lipid peroxidation in the pancreas, and serum amylaseactivity were increased significantly. Pretreatment with melatonin (10 or 50 mg/kg body wt) 30 min before each cerulein injection resulted in a significant reduction in pancreatic edema and the levels of lipid peroxidation. Serum amylase activity, however, was not significantly influenced by eitherdose of melatonin. Moreover, we found that cerulein administration was associated with stomach edema as well as high levels of lipid peroxidation in the stomach and small intestine, which were also reduced by melatonin. Melatonin's protective effects in cerulein-treated rats presumably relate to its radical scavenging ability and to other antioxidative processes induced by melatonin.

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Documento generato il 25/09/20 alle ore 00:12:44