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Titolo:
Mis-specification of cortical identity in a fission yeast PAK mutant
Autore:
Sawin, KE; Hajibagheri, MAN; Nurse, P;
Indirizzi:
Imperial Canc Res Fund, Cell Cycle Lab, London WC2A 3PX, England Imperial Canc Res Fund London England WC2A 3PX London WC2A 3PX, England Imperial Canc Res Fund, Electron Microscopy Lab, London WC2A 3PX, England Imperial Canc Res Fund London England WC2A 3PX London WC2A 3PX, England
Titolo Testata:
CURRENT BIOLOGY
fascicolo: 22, volume: 9, anno: 1999,
pagine: 1335 - 1338
SICI:
0960-9822(19991118)9:22<1335:MOCIIA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCHIZOSACCHAROMYCES-POMBE; CELL POLARITY; PROTEIN-KINASE; F-ACTIN; GROWTH; CYCLE; MORPHOGENESIS; LOCALIZATION; CDC42P; GENES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Sawin, KE Univ Edinburgh, Inst Cell & Mol Biol, Swann Bldg,Mayfield Rd, Edinburgh EH9 3JR, Midlothian, Scotland Univ Edinburgh Swann Bldg,Mayfield RdEdinburgh Midlothian Scotland EH9 3JR
Citazione:
K.E. Sawin et al., "Mis-specification of cortical identity in a fission yeast PAK mutant", CURR BIOL, 9(22), 1999, pp. 1335-1338

Abstract

The regulation of cell polarity in the fission yeast Schizosaccharomyces pombe is apparent in the restriction of extensile growth to the two ends of a cylindrically shaped cell, and in a specific transition-termed 'new-end take-off' (NETO)-between monopolar and bipolar growth mid-way through the cell cycle [1], Several genes have been identified that affect one or more aspects of cell polarity (reviewed in [2,3]), and the molecular pathways regulating cell polarity in fission yeast appear to be conserved among eukaryotes [3-9], but it is less clear how the proteins involved organize polarity at the level of the entire cell. Here, we describe novel cytological markers of cell polarity in fission yeast and their unusual localization in the monopolar growth mutant orb2-34, which carries a non-lethal mutation in the essential gene shk1(+)/pak1(+)/orb2(+), which encodes a p21-activated kinase (PAK) family member [8-12]. Our results suggest that, in contrast to other monopolar-growing mutants, the monopolar phenotype of the orb2-34 mutant might not be due to a defect in activating end growth per se, but rather reflects a failure of one of the cell ends to maintain the molecular properties that identify an end. Thus, one role of the Shk1/Pak1 kinase in vivo might be to contribute to how a cell recognizes its ends as sites for growth.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 06:44:34