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Titolo:
Effects of low-dose dopexamine on splanchnic oxygenation during major abdominal surgery
Autore:
Muller, M; Boldt, J; Schindler, E; Sticher, J; Kelm, C; Roth, S; Hempelmann, G;
Indirizzi:
Univ Giessen, Dept Anaesthesiol & Intens Care Med, D-35392 Giessen, Germany Univ Giessen Giessen Germany D-35392 Care Med, D-35392 Giessen, Germany Univ Giessen, Dept Gen & Thorac Surg, D-35392 Giessen, Germany Univ Giessen Giessen Germany D-35392 orac Surg, D-35392 Giessen, Germany Klinikum Stadt Ludwigshafen, Dept Anaesthesiol & Intens Care Med, Ludwigshafen, Germany Klinikum Stadt Ludwigshafen Ludwigshafen Germany Ludwigshafen, Germany
Titolo Testata:
CRITICAL CARE MEDICINE
fascicolo: 11, volume: 27, anno: 1999,
pagine: 2389 - 2393
SICI:
0090-3493(199911)27:11<2389:EOLDOS>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHOSPHATE-BUFFERED SOLUTION; GASTRIC INTRAMUCOSAL PH; BLOOD-FLOW; CARDIAC-SURGERY; SEPTIC SHOCK; MUCOSAL PH; TONOMETRY; DOPAMINE; ISCHEMIA; ENDOTOXEMIA;
Keywords:
gastrointestinal blood flow; splanchnic oxygenation; tissue Po-2; gastric tonometry; gastric intramucosal Pco(2); monitoring; catecholamines; dopexamine; hemodynamics; major abdominal surgery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Muller, M Univ Giessen, Dept Anaesthesiol & Intens Care Med, Rudolf Buchheim Str 7, D-35392 Giessen, Germany Univ Giessen Rudolf Buchheim Str 7 Giessen Germany D-35392 many
Citazione:
M. Muller et al., "Effects of low-dose dopexamine on splanchnic oxygenation during major abdominal surgery", CRIT CARE M, 27(11), 1999, pp. 2389-2393

Abstract

Objective: To study the influence of low-dose dopexamine on splanchnic oxygenation during major abdominal surgery. Design: Prospective, randomized, placebo-controlled study. Setting: University hospital. Patients: Eighteen adult patients undergoing elective major abdominal surgery. Interventions: The patients received either dopexamine at 1 mu g/kg/min (group A, n = 9) or 0.9% saline as control (group B, n = 9),Measurements and Results: To assess the splanchnic oxygenation, intestinaltissue Po-2 (P(tiss)o(2)) and gastric intramucosal Pco(2) (PmucCO2) were measured, and the Pco(2) gap (P(muc)co(2) - Paco(2)) was calculated at baseline (T1) and after an infusion period of 60 mins (T2), There was no difference between the groups in the global oxygen transport parameters, Low-dose dopexamine increases P(tlss)o(2) on the serosal side of the small bowel (Delta P(tiss)o(2), 17 +/- 24 mm Hg in group A vs. -5 +/- 10 in group B), The changes in P(tiss)o(2) at the serosal side of the colon after dopexamine demonstrated a nonsignificant increase (Delta P(tiss)o(2), 7 +/- 11 mm Hg in group A vs. -11 +/- 23 mm Hg in group B), In both groups, the Pco(2) gap (group A, 6 +/- 7 mm Hg [T1] and 5 +/- 6 mm Hg [T2], vs. group B, 9 +/- 10 mmHg [T1] and 12 +/- 10 mm Hg [T2]) remained unchanged compared with the baseline,Conclusion: It is concluded that low-dose dopexamine improves P(tiss)o(2) at the serosal side of the gut, preferably at the small bowel, However, low-dose dopexamine did not improve gastric P(muc)co(2) .

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 22:12:24