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Titolo:
Effect of glucose load on the transport kinetics of palmitic acid in the human placenta: An in vitro study
Autore:
Nandakumaran, M; Al-Rayyes, S; Al-Yatama, M; Sugathan, TN;
Indirizzi:
Kuwait Univ, Dept Obstet & Gynaecol, Fac Med, Safat 13110, Kuwait Kuwait Univ Safat Kuwait 13110 & Gynaecol, Fac Med, Safat 13110, Kuwait Kuwait Univ, Dept Community Med, Fac Med, Safat 13110, Kuwait Kuwait UnivSafat Kuwait 13110 mmunity Med, Fac Med, Safat 13110, Kuwait
Titolo Testata:
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
fascicolo: 9, volume: 26, anno: 1999,
pagine: 669 - 673
SICI:
0305-1870(199909)26:9<669:EOGLOT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFUSED HUMAN-PLACENTA; FREE FATTY-ACIDS; PREGNANCY; INVITRO; RAT;
Keywords:
human placenta; in vitro; maternal-foetal exchange; palmitic acid; transport kinetics; tritiated water;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Nandakumaran, M Kuwait Univ, Dept Obstet & Gynaecol, Fac Med, POB 24923, Safat 13110, Kuwait Kuwait Univ POB 24923 Safat Kuwait 13110 at 13110, Kuwait
Citazione:
M. Nandakumaran et al., "Effect of glucose load on the transport kinetics of palmitic acid in the human placenta: An in vitro study", CLIN EXP PH, 26(9), 1999, pp. 669-673

Abstract

1. A paucity of data relating to free fatty acid (FFA) transport in the human placenta in non-steady state conditions prompted us to undertake the present study.2. The transport kinetics of palmitic acid in non-steady state conditions have been investigated in vitro using human perfused placental lobules, Theeffects of varying glucose concentrations on maternal-foetal transport of the FFA were also investigated to mimic the hyperglycaemic states of human diabetic pregnancies,3. National Cancer Tissue Culture medium diluted with Earle's buffered salt solution was used as the perfusate, [C-14]-Palmitic acid, along with tritiated water as a reference, was injected as a bolus into the maternal arterial perfusate and perfusate samples were collected from the venous outflow for a period of 5 min,4. The transport fraction (TF) of palmitic acid, expressed as percentage of the injected bolus, averaged 3.45+/-0.15% in five perfusions, representing 9.2+/-1.3% of the corresponding reference marker TF, Kinetic parameters, as well as TF indices of palmitic acid expressed in relation to the reference substance, did not differ significantly between perfusions with a physiological glucose load and those with hyperglycaemic concentrations of glucose of 27.8 and 55.6 mmol/L.5. The present study shows that hyperglycaemia per se does not significantly alter palmitic acid transport kinetics in vitro in the human perfused placental lobule.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/21 alle ore 18:12:00