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Titolo:
A novel class of eukaryotic zinc-binding proteins is required for disease resistance signaling in barley and development in C-elegans
Autore:
Shirasu, K; Lahaye, T; Tan, MW; Zhou, FS; Azevedo, C; Schulze-Lefert, P;
Indirizzi:
John Innes Ctr Plant Sci Res, Sainsbury Lab, Norwich NR4 7UH, Norfolk, England John Innes Ctr Plant Sci Res Norwich Norfolk England NR4 7UH olk, England Massachusetts Gen Hosp, Dept Mol Biol, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Mol Biol, Boston, MA 02114 USA Harvard Univ, Sch Med, Dept Genet, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 ch Med, Dept Genet, Boston, MA 02115 USA
Titolo Testata:
CELL
fascicolo: 4, volume: 99, anno: 1999,
pagine: 355 - 366
SICI:
0092-8674(19991112)99:4<355:ANCOEZ>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
POWDERY MILDEW INTERACTION; PROGRAMMED CELL-DEATH; OXIDATIVE BURST; GENE ML-A12; PLANTS; ARABIDOPSIS; PATHOGEN; FINGER; LOCUS; RESPONSES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Schulze-Lefert, P John Innes Ctr Plant Sci Res, Sainsbury Lab, Colney Lane, Norwich NR4 7UH,Norfolk, England John Innes Ctr Plant Sci Res Colney LaneNorwich Norfolk England NR4 7UH
Citazione:
K. Shirasu et al., "A novel class of eukaryotic zinc-binding proteins is required for disease resistance signaling in barley and development in C-elegans", CELL, 99(4), 1999, pp. 355-366

Abstract

Barley Rar1 is a convergence point in the signaling of resistance to powdery mildew, triggered by multiple race-specific resistance (R) genes. Rar1 is shown to function upstream of H2O2 accumulation in attacked host cells, which precedes localized host cell death. We isolated Rar1 by map-based cloning. The sequence of the deduced 25.5 kDa protein reveals two copies of a 60-amino acid domain, CHORD, conserved in tandem organization in protozoa, plants, and metazoa. CHORD defines a novel eukaryotic Zn2+-binding domain. Silencing of the C. elegans CHORD-containing gene, chp, results in semisterility and embryo lethality, suggesting an essential function of the wild-type gene in nematode development. Our findings indicate that plant R genes have recruited a fundamental cellular control element for signaling of disease resistance and cell death.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 19:16:31