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Titolo:
Ingestion of green tea rapidly decreases prostaglandin E-2 levels in rectal mucosa in humans
Autore:
August, DA; Landau, J; Caputo, D; Hong, JG; Lee, MJ; Yang, CS;
Indirizzi:
Rutgers State Univ, Coll Pharm, Canc Res Lab, Piscataway, NJ 08854 USA Rutgers State Univ Piscataway NJ USA 08854 Lab, Piscataway, NJ 08854 USA Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Surg, New Brunswick, NJ 08901 USA Univ Med & Dent New Jersey New Brunswick NJ USA 08901 swick, NJ 08901 USA Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Clin Res Ctr, NewBrunswick, NJ 08901 USA Univ Med & Dent New Jersey New Brunswick NJ USA 08901 swick, NJ 08901 USA Canc Inst New Jersey, New Brunswick, NJ 08901 USA Canc Inst New Jersey New Brunswick NJ USA 08901 w Brunswick, NJ 08901 USA
Titolo Testata:
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
fascicolo: 8, volume: 8, anno: 1999,
pagine: 709 - 713
SICI:
1055-9965(199908)8:8<709:IOGTRD>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED COLON CARCINOGENESIS; SENCAR MOUSE SKIN; BLACK TEA; (-)-EPIGALLOCATECHIN GALLATE; A/J MICE; CANCER CHEMOPREVENTION; CELL-PROLIFERATION; LUNG TUMORIGENESIS; TUMOR INITIATION; DRINKING-WATER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Yang, CS Rutgers State Univ, Coll Pharm, Canc Res Lab, 164 Frelinghuysen Rd, Piscataway, NJ 08854 USA Rutgers State Univ 164 Frelinghuysen Rd Piscataway NJ USA 08854 A
Citazione:
D.A. August et al., "Ingestion of green tea rapidly decreases prostaglandin E-2 levels in rectal mucosa in humans", CANC EPID B, 8(8), 1999, pp. 709-713

Abstract

The objective of this Phase VII study was to assess the potential for green tea to be used as a colorectal cancer chemopreventive agent. This study measured the dose-related biological effects of administration of a single dose of green tea on the rectal mucosa of normal volunteers, Volunteers wereadmitted to the Robert Wood Johnson Medical School Clinical Research Center for 24 h. Baseline blood and rectal biopsy samples were obtained before the volunteers drank 0.6, 1.2, or 1.8 g of green tea solids dissolved in warm water. Blood samples were taken 2, 4, 8, and 24 h after the tea administration. Rectal biopsies were obtained at 4, 8, and 24 h. Prostaglandin E-2 (PGE(2)) levels were analyzed by ELISA. Tea polyphenol levels in the blood, urine, and rectal tissue were measured by high-performance liquid chromatography using a Coulochem electrode array detection system. Statistical comparisons were made using ANOVA. Decreased levels of PGE(2) in rectal mucosa were observed at 4 and 8 h after consumption of green tea. There was no correlation between inhibition of PGE(2) and tissue or plasma levels of tea polyphenols. Ten of 14 subjects demonstrated a response to green tea, as evidenced by at least a 50% inhibition of PGE(2) levels at 4 h, We conclude thatgreen tea constituents have biological activity in inhibiting PGE(2) synthesis. Given the 71% "response rate," we believe these data support the study of green tea as a colorectal chemopreventive agent in more long-term Phase II trials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 14:12:32