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Titolo:
Malignant pleural mesothelioma
Autore:
Gross-Goupil, M; Ruffie, P;
Indirizzi:
Inst Gustave Roussy, F-94805 Villejuif, France Inst Gustave Roussy Villejuif France F-94805 , F-94805 Villejuif, France
Titolo Testata:
BULLETIN DU CANCER
, , anno: 1999, supplemento:, 3
pagine: 43 - 54
SICI:
0007-4551(199910):<43:MPM>2.0.ZU;2-U
Fonte:
ISI
Lingua:
FRE
Soggetto:
LEUKEMIA GROUP-B; PHASE-II TRIAL; PROGNOSTIC FACTORS; LUNG-CANCER; EXTRAPLEURAL PNEUMONECTOMY; MULTIMODALITY THERAPY; PHOTODYNAMIC THERAPY; CONSECUTIVE PATIENTS; ALPHA-INTERFERON; MITOMYCIN-C;
Keywords:
mesothelioma; pleura;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Gross-Goupil, M Inst Gustave Roussy, Rue Camille Desmoulins, F-94805 Villejuif, France Inst Gustave Roussy Rue Camille Desmoulins Villejuif France F-94805
Citazione:
M. Gross-Goupil e P. Ruffie, "Malignant pleural mesothelioma", B CANCER, 1999, pp. 43-54

Abstract

The malignant pleural mesothelioma is a rare tumor of the general population. The exposure of asbestose still remains the main factor of risk, found in 72 to 95% of the patients. The diagnosis is difficult. The symptoms are poor, with most often chronic pleural effusion, with dyspnea, associated with localized chest pain. The histological diagnosis is made on thoracoscopic biopsy. Analysis of the histochemical profile (PAS-D, hyaluronidase, vimentine), the use of immunochemistry (CEA, keratines), and electron microscopy can facilitate the making of the diagnosis. There is 3 different entitiesof malignant mesothelioma: the epithelial type, mixed, and sarcomatous. The staging is based on thoracic scanner to determinate the extent of the tumor, her relation with the local structures, and the possible involvement ofthe mediastinal lymphnodes. There is several staging systems, the Butchart's staging classification, and most recently the IMIG (International Mesothelioma Interest Group) classification. The significant prognostic factors, in multivariate analysis are: the stage of the disease, the histologic type, and the performance status of he patient. The current therapeutic maneuvers (survery, chemotherapy, radiotherapy) did not show significant improvement of the survival The radical surgery, like pleuropneumonectomy, should beconsider only for patients with an early stage of the disease. The chemotherapy, with single agent or in combination, still remains disappointing, with objective response rates between 20 and 30%, in best cases. The curativeradiotherapy is limited by the importance of the target-volume, and the proximity of critical organ ((lung, heart). Only the preventive radiotherapy,on scars, niddle or surgical tracts is recommended. Immunotherapy, by systemic or intracavitary administration, remains limited because of the toxicity, especially infection. All of the therapeutic maneuvers should be proposed in clinical trials.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:04:52