Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Evidence for opiate-activated NMDA processes masking opiate analgesia in rats
Autore:
Celerier, E; Laulin, JP; Larcher, A; Le Moal, M; Simonnet, G;
Indirizzi:
Univ Bordeaux 2, INSERM, U259, Lab Psychobiol Comportements Adaptatifs, F-33077 Bordeaux, France Univ Bordeaux 2 Bordeaux France F-33077 tatifs, F-33077 Bordeaux, France
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1, volume: 847, anno: 1999,
pagine: 18 - 25
SICI:
0006-8993(19991113)847:1<18:EFONPM>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE-C; NALOXONE-PRECIPITATED WITHDRAWAL; RECEPTOR ANTAGONIST MK-801; HORN NOCICEPTIVE NEURONS; AMINO-ACID ANTAGONISTS; MORPHINE-TOLERANCE; DORSAL HORN; FIBER STIMULATION; SPINAL-CORD; DEPENDENCE;
Keywords:
morphine; fentanyl; analgesia; naloxone-precipitated hyperalgesia; MK-801; NMDA pain facilitatory processes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Simonnet, G Univ Bordeaux 2, INSERM, U259, Lab Psychobiol Comportements Adaptatifs, 1 Rue Camille St Saens, F-33077 Bordeaux, France Univ Bordeaux 2 1 Rue Camille St Saens Bordeaux France F-33077
Citazione:
E. Celerier et al., "Evidence for opiate-activated NMDA processes masking opiate analgesia in rats", BRAIN RES, 847(1), 1999, pp. 18-25

Abstract

The acute interaction between opioid receptors and N-methyl-D-aspartate (NMDA) receptors on nociception was examined in rats using tail-flick and paw-pressure vocalisation tests. When injected at various times (1 to 6 h) after morphine (5 to 20 mg/kg, i.v.) or fentanyl (4 X 40 mu g/kg, i.v.), the opioid receptor antagonist naloxone (1 mg/kg, s.c.) not only abolished the opiate-induced increase in nociceptive threshold, but also reduced it below the basal value (hyperalgesia). The noncompetitive NMDA receptor antagonistMK-801 (0.15 or 0.30 mg/kg, s.c.) prevented the naloxone-precipitated hyperalgesia and enhanced the antinociceptive effects of morphine (7.5 mg/kg, i.v.) and fentanyl (4 X 40 mu g/kg, i.v.). These results indicate that the antinociceptive effects of morphine and fentanyl, two opiate analgesics widely used in humans in the management of pain, are blunted by concomitant NMDA-dependent opposing effects which are only revealed when the predominant antinociceptive effect is sharply blocked by naloxone. This study provides new rationale for beneficial adjunction of NMDA receptor antagonists with opiates for relieving pain by preventing pain facilitatory processes triggered by opiate treatment per se. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 20:07:18