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Titolo:
Effects of inhaled nitric oxide and high-frequency ventilation in rabbits with meconium aspiration
Autore:
Huang, QW; Sun, B; Gao, F; Zhang, YM; Wu, Y; Zhu, LW; Lindwall, R;
Indirizzi:
Shanghai Med Univ, Childrens Hosp, Res Inst, Shanghai 200032, Peoples R China Shanghai Med Univ Shanghai Peoples R China 200032 00032, Peoples R China Shanghai Childrens Hosp, Dept Pediat, Shanghai 200040, Peoples R China Shanghai Childrens Hosp Shanghai Peoples R China 200040 Peoples R China Danderyd Hosp, Dept Anaesthesiol & Intens Care, S-18288 Danderyd, Sweden Danderyd Hosp Danderyd Sweden S-18288 ens Care, S-18288 Danderyd, Sweden
Titolo Testata:
BIOLOGY OF THE NEONATE
fascicolo: 6, volume: 76, anno: 1999,
pagine: 374 - 382
SICI:
0006-3126(199912)76:6<374:EOINOA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERSISTENT PULMONARY-HYPERTENSION; RESPIRATORY-DISTRESS SYNDROME; OSCILLATORY VENTILATION; EXOGENOUS SURFACTANT; PLATELET-AGGREGATION; MULTICENTER TRIAL; PRETERM INFANTS; BLEEDING-TIME; OXYGENATION; THERAPY;
Keywords:
high-frequency ventilation; meconium aspiration syndrome; nitric oxide; platelet; respiratory therapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Sun, B Shanghai Med Univ, Childrens Hosp, Res Inst, 183 Feng Lin Rd, Shanghai 200032, Peoples R China Shanghai Med Univ 183 Feng Lin Rd Shanghai Peoples R China 200032
Citazione:
Q.W. Huang et al., "Effects of inhaled nitric oxide and high-frequency ventilation in rabbits with meconium aspiration", BIOL NEONAT, 76(6), 1999, pp. 374-382

Abstract

Aim: To evaluate effects of inhaled nitric oxide (iNO) in experimental meconium aspiration treated with high-frequency (HFV) or conventional mechanical ventilation (CMV). Ventilated adult rabbits had meconium instilled intratracheally resulting in respiratory failure as evidenced by more than 50% reduction of dynamic lung compliance (Cdyn) and increase in mean oxygenationindex (OI) from 1 to 16. The animals were then allocated to 2 groups treated without (control) or with iNO at 20 ppm (NO). In each group the animals were initially ventilated with CMV or HFV mode for 3 h and then in a crossover fashion with HFV or CMV for another 3h (CMV --> HFV, HFV --> CMV), respectively. In the first 3 h of treatment, the animals subjected to HFV-CMV in the control, and those with both HFV-CMV and CMV-HFV in the NO group had significantly reduced OI. in the subsequent 3 h, the animals in the controlgroup with CMV-HFV did not improve in OI and those with HFV-CMV had deteriorated. In the NO group with both CMV-HFV and HFV-CMV moderate improvement of OI was observed. Platelet aggregation capability and counts were significantly decreased and bleeding time prolonged in animals receiving iNO treatment. These results suggest that both HFV alone and a combined treatment ofiNO with either CMV or HFV are more effective in improving blood oxygenation than that of CMV in this animal model. The influence of iNO an platelet aggregation should be considered. Copyright (C) 1999 S. Karger AG. Basel.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 04:10:13