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Titolo:
Characterization of ocular pharmacokinetics of tilisolol after instillation into anesthetized rabbits
Autore:
Sasaki, H; Yamamura, K; Mukai, K; Nishida, K; Nakamura, J; Nakashima, M; Ichikawa, M;
Indirizzi:
Nagasaki Univ, Sch Med, Dept Hosp Pharm, Nagasaki 8528501, Japan Nagasaki Univ Nagasaki Japan 8528501 Hosp Pharm, Nagasaki 8528501, Japan Nagasaki Univ, Sch Pharmaceut Sci, Nagasaki 8528521, Japan Nagasaki Univ Nagasaki Japan 8528521 maceut Sci, Nagasaki 8528521, Japan
Titolo Testata:
BIOLOGICAL & PHARMACEUTICAL BULLETIN
fascicolo: 11, volume: 22, anno: 1999,
pagine: 1253 - 1255
SICI:
0918-6158(199911)22:11<1253:COOPOT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISPOSITION; DELIVERY; EYES;
Keywords:
ocular pharmacokinetics; tilisolol; diffusion model; ocular penetration; drug delivery system; tear deficiency;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
11
Recensione:
Indirizzi per estratti:
Indirizzo: Sasaki, H Nagasaki Univ, Sch Med, Dept Hosp Pharm, 1-7-1 Sakamoto, Nagasaki 8528501,Japan Nagasaki Univ 1-7-1 Sakamoto Nagasaki Japan 8528501 28501,Japan
Citazione:
H. Sasaki et al., "Characterization of ocular pharmacokinetics of tilisolol after instillation into anesthetized rabbits", BIOL PHAR B, 22(11), 1999, pp. 1253-1255

Abstract

The purpose of this study was to characterize the ocular pharmacokinetics of a beta-blocker, tilisolol, after instillation into anesthetized rabbits using a mathematical model including a diffusion process. The samples were analyzed by HPLC. Anesthetized rabbit was used as a model of tear secretiondeficiency. Anesthetized rabbits showed higher drug concentration in the tear fluid and aqueous humor after instillation than unanesthetized rabbits. A mathematical model including a diffusion process and in vivo penetrationparameters well described the concentrations of tilisolol in the aqueous humor after instillation in anesthetized rabbits.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 08:22:55