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Titolo:
20-HETE agonists and antagonists in the renal circulation
Autore:
Alonso-Galicia, M; Falck, JR; Reddy, KM; Roman, RJ;
Indirizzi:
Med Coll Wisconsin, Dept Physiol, Milwaukee, WI 53226 USA Med Coll Wisconsin Milwaukee WI USA 53226 hysiol, Milwaukee, WI 53226 USA Univ Texas, SW Med Ctr, Dept Mol Genet, Dallas, TX 75235 USA Univ Texas Dallas TX USA 75235 Ctr, Dept Mol Genet, Dallas, TX 75235 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
fascicolo: 5, volume: 277, anno: 1999,
pagine: F790 - F796
SICI:
0363-6127(199911)277:5<F790:2AAAIT>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RATS; ARACHIDONIC-ACID; METABOLITES; CYTOCHROME-P-450; VASOCONSTRICTOR; EICOSANOIDS; RESPONSES; PRESSURE; CASCADE; ENZYME;
Keywords:
cytochrome P-450; renal arterioles; vasoconstriction; hydroxyeicosatetraenoic acids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Roman, RJ Med Coll Wisconsin, Dept Physiol, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA Med Coll Wisconsin 8701 Watertown Plank Rd Milwaukee WI USA 53226
Citazione:
M. Alonso-Galicia et al., "20-HETE agonists and antagonists in the renal circulation", AM J P-REN, 277(5), 1999, pp. F790-F796

Abstract

The present study examined the effects of a series of 20-hydroxyeicosatetraenoic acid (20-HETE) derivatives on the diameter of renal arterioles to determine the structural requirements of the vasoconstrictor response to 20-HETE. The vascular responses to 5-, 8-, 12-, 15-, 19-, 20-, 21-HETEs, arachidonic acid (AA), and saturated, partially saturated, dimethyl, carboxyl, and 19-carbon derivatives of 20-HETE (10(-8) to 10(-6) M) were assessed in rat renal interlobular arteries (65-125 mu m). 20-HETE, 21-HETE, dimethyl-20-HETE, and a partially saturated derivative of 20-HETE, 20-hydroxyeicosa-5(Z),14(Z)-dienoic acid, reduced vessel diameter by 19 +/- 3, 17 +/- 3, 16 +/-2, and 28 +/- 2%, respectively. In contrast, 5-, 8-, 12-, 15-, and 19-HETE, AA, saturated, partially saturated, carboxyl, and the 19-carbon derivatives of 20-HETE had no effect on vessel diameter. Pretreatment with 5-, 15-, and 19-HETE, the Ig-carbon derivative or 20-hydroxyeicosa-6(Z),15(Z)-dienoic acid (1 mu M) completely blocked the vasoconstrictor response to 20-HETE in renal arterioles. Pretreatment with AA, carboxyl, saturated 19-carbon, and saturated 20-HETE derivatives (1 mu M) partially blocked the response, whereas 8- and 12-HETE (1 mu M) had no effect on the vasoconstrictor response to 20-HETE. These findings suggest that 20-HETE agonists and antagonists require a carboxyl or an ionizable group on carbon 1 and a double bond nearthe 14 or 15 carbon. 20-HETE agonists also require a functional group capable of hydrogen bonding on carbon 20 or 21, whereas antagonists lack this reactive group.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:33:00