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Titolo:
Effects of insulin-like growth factor-1 in motor nerve regeneration after nerve transection and repair vs. nerve crushing injury in the rat
Autore:
Lutz, BS; Wei, FC; Ma, SF; Chuang, DCC;
Indirizzi:
Univ Hosp & Med Coll Hannover, Dept Plast Hand & Reconstruct Surg, D-30659Hannover, Germany Univ Hosp & Med Coll Hannover Hannover Germany D-30659 Hannover, Germany Chang Gung Mem Hosp, Coll Med, Dept Plast & Reconstruct Surg, Taipei 10591, Taiwan Chang Gung Mem Hosp Taipei Taiwan 10591 truct Surg, Taipei 10591, Taiwan Chang Gung Mem Hosp, Coll Med, Microsurg Res Lab, Taipei 10591, Taiwan Chang Gung Mem Hosp Taipei Taiwan 10591 rg Res Lab, Taipei 10591, Taiwan Chang Gung Univ, Taipei, Taiwan Chang Gung Univ Taipei TaiwanChang Gung Univ, Taipei, Taiwan
Titolo Testata:
ACTA NEUROCHIRURGICA
fascicolo: 10, volume: 141, anno: 1999,
pagine: 1101 - 1106
SICI:
0001-6268(1999)141:10<1101:EOIGFI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
SCIATIC-NERVE; FACTOR-I; NEUROTROPHIC FACTOR; SCHWANN-CELLS; IGF-I; MUSCLE; EXPRESSION; GAP-43; MOTONEURONS; MECHANISMS;
Keywords:
insulin-like growth factor-I; never transection; motor nerve regeneration; axonal guidance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Lutz, BS Univ Hosp & Med Coll Hannover, Dept Plast Hand & Reconstruct Surg, Podbielskistr 380, D-30659 Hannover, Germany Univ Hosp & Med Coll Hannover Podbielskistr 380 Hannover Germany D-30659
Citazione:
B.S. Lutz et al., "Effects of insulin-like growth factor-1 in motor nerve regeneration after nerve transection and repair vs. nerve crushing injury in the rat", ACT NEUROCH, 141(10), 1999, pp. 1101-1106

Abstract

Despite highest standards in nerve repair, functional recovery following nerve transection still remains unsatisfactory. Non-specific re-innervation of target organs are regarded as one reason for a poor functional outcome. Insulin-like growth factor-1 (IGF-1) has demonstrated promoting effects on sciatic nerve regeneration after crushing injury. Similarly, IGF-1 has shown a direct inductive effect on motoneuron growth associated protein-43 (GAP-43) which is believed to play a role in axon guidance during development. Based on this fact we have examined the trophic effects of recombinant human IGF-1 on peripheral motor nerve regeneration following transection and epineural repair in rats median nerve. RhIGF-1 (0.5 mg/kg/rat) was administered subcutaneously to the neck of the repaired side for 14 days postoperation. Accuracy of reinnervation of the flexor carpi radialis muscle motoneuron pool was studied by sequential retrograde double labelling technique. Motor recovery was test-ed with the grasping test. No significant differences between experimental and control animals in accuracy of reinnervation and in recovery of muscle power could be demonstrated. Non-specific re-innervation of the flexor carpi radialis muscle was found in 23.2% in the experimental group and in 24.2% in the control group. These results demonstrate that systemically applied rhIGF-1 failed to improve functional motor recovery after nerve transection and repair in the rat as it was demonstrated after nerve crushing injury in several studies. Furthermore, systemically applied IGF-I did not improve accuracy of re-innervation after axotomy and repair inadult rats.

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Documento generato il 29/03/20 alle ore 01:57:05