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Titolo:
Expression of p53 and bcl-2 in cervical carcinomas and their premalignant lesions
Autore:
Diakomanolis, E; Dimitrakakis, C; Kymionis, G; Papaspyrpou, I; Rodolakis, A; Voulgaris, Z; Michalas, S;
Indirizzi:
Univ Athens, Alexandra Hosp, Dept Obstet & Gynecol 1, Athens, Greece Univ Athens Athens Greece Hosp, Dept Obstet & Gynecol 1, Athens, Greece
Titolo Testata:
7TH BIENNIAL MEETING OF THE INTERNATIONAL GYNECOLOGIC CANCER SOCIETY
, , anno: 1999,
pagine: 381 - 384
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Monografia
Settore Disciplinare:
Clinical Medicine
Citazioni:
2
Recensione:
Indirizzi per estratti:
Indirizzo: Diakomanolis, E Univ Athens, Alexandra Hosp, Dept Obstet & Gynecol 1, Athens, Greece Univ Athens Athens Greece t & Gynecol 1, Athens, Greece
Citazione:
E. Diakomanolis et al., "Expression of p53 and bcl-2 in cervical carcinomas and their premalignant lesions", 7TH BIENNIAL MEETING OF THE INTERNATIONAL GYNECOLOGIC CANCER SOCIETY, 1999, pp. 381-384

Abstract

The purpose of this study was to assess the expression and clinical significance of bcl-2 and p53 in the progression of cervical neoplasias. One hundred seventy one cervical lesions, consisting of normal cervical epithelium,condyloma lesions, CIN (cervical intraepithelial neoplasia) lesions and cervical carcinomas were examined immunohistochemically. Twenty-three specimens showed p53 expression [3/20 (15%) CIN III, 18/63 (29%) ISCC (invasive squamous cervical carcinoma) and 2/18 (11%) adenocarcinomas] while 63 cases expressed the bcl-2 gene [10/13 (77%) normal, 0/14(0%) condylomas, 6/23 (26%) CIN I, 9/20 (45%) CIN II, 15/20 (75%) CIN III, 18/63 (29%) ISCC and 5/18 (28%) adenocarcinomas]. The positivity of bcl-2 has being significantly increased in line with grade of CIN (p=0.02) while similar correlation was notobserved in p53. In cervical cancer patients, expression of bcl-2 was correlated to a better 5-year survival (p<0.01) while no prognostic significance of p53 expression was found.

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Documento generato il 02/04/20 alle ore 19:05:09