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Titolo:
Expression of biliary antigen and its clinical significance in hepatocellular carcinoma
Autore:
Yoon, DS; Jeong, J; Park, YN; Kim, KS; Kwon, SW; Chi, HS; Park, C; Kim, BR;
Indirizzi:
Yonsei Univ, Coll Med, Dept Surg, Seoul, South Korea Yonsei Univ Seoul South Korea , Coll Med, Dept Surg, Seoul, South Korea Yonsei Univ, Coll Med, Dept Pathol, Seoul, South Korea Yonsei Univ SeoulSouth Korea Coll Med, Dept Pathol, Seoul, South Korea Kwandong Univ, Coll Med, Dept Surg, Kangnung, South Korea Kwandong Univ Kangnung South Korea ed, Dept Surg, Kangnung, South Korea Pochon CHA Univ, Coll Med, Dept Surg, Kyungkido, South Korea Pochon CHA Univ Kyungkido South Korea Dept Surg, Kyungkido, South Korea
Titolo Testata:
YONSEI MEDICAL JOURNAL
fascicolo: 5, volume: 40, anno: 1999,
pagine: 472 - 477
SICI:
0513-5796(199910)40:5<472:EOBAAI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-SUPPRESSOR GENE; HEPATITIS-B VIRUS; P53 GENE; DIFFERENTIAL-DIAGNOSIS; MONOCLONAL-ANTIBODY; NATURAL-HISTORY; MUTATIONS; OVEREXPRESSION; TISSUE; CELLS;
Keywords:
hepatocellular carcinoma; biliary antigen; clinical significance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Park, YN Yonsei Univ, Coll Med, Dept Pathol, Yongdong Severance Hosp, Yongdong POB 1217, Seoul 135270, South Korea Yonsei Univ Yongdong POB 1217 Seoul South Korea 135270 uth Korea
Citazione:
D.S. Yoon et al., "Expression of biliary antigen and its clinical significance in hepatocellular carcinoma", YONSEI MED, 40(5), 1999, pp. 472-477

Abstract

In order to classify the hepatocellular carcinomas (HCCs) which had diverse clinicopathologic characteristics, we divided HCCs into two groups according to the expression of biliary antigen on the basis of the hypothesis that the hepatocyte and biliary epithelial cell originate from the same precursor cell, and then we investigated the clinical and pathologic characteristics in the two groups. Forty HCC cases with no preoperative treatment and at least two-year follow-up data were selected among 202 cases of HCC files from 1991 to 1995. Expression of biliary antigen (AE1, cytokeratin 19), p53, AFP, and Ki-67 in the tumor tissue were assessed by immunohistochemistry. Positive cytokeratin 19 was noted in one case (2.5%); AE1 was detected in 40% of patients; p53 was overexpressed in 20% of patients; and AFP was detected in 45% of patients. No statistical difference between the biliary antigen positive group (16 cases) and the negative group (24 cases) were noted in terms of mean age, sex, presurgical serum AFP level, Child class, and tumor size. HBsAg positive race was 66.7% for the biliary antigen (-) group and 93.8% for the biliary antigen (+) group with a statistically significantdifference (p=0.048). The number of cases for Edmonson-Steiner grade I/II and III/IV were 15 and 9 in the biliary antigen (-) group, and 4 and 12 in the biliary antigen (+) group, respectively, with a statistically significant difference (p=0.024). The 1, 3 and 5-year disease-free survival races were 69.7, 40.9 and 40.9% for the biliary antigen (-) group and 73.7, 39.1, 39.1% for the biliary antigen (+) group with no statistically significant difference. The 1, 3 and 5-year overall survival rates were 91.7, 73.8, 66.4%for the biliary antigen (-) group and 68.8, 34.4, 34.4% for the biliary antigen (+) group, with a significantly greater overall survival rate for thebiliary antigen negative group (p=0.045). Poor histopathological differentiation, a high HBsAg positive rate and poor overall survival rate were noted in the biliary antigen positive group and the differences were statistically significant. In conclusion, HCCs with positive biliary antigen, which originates from more primitive cells, is suggested to he more aggressive than HCCs with negative biliary antigen.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 19:42:18