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Titolo:
Long-term potentiation in the amygdala: a mechanism for emotional learningand memory
Autore:
Maren, S;
Indirizzi:
Univ Michigan, Dept Psychol, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 ept Psychol, Ann Arbor, MI 48109 USA Univ Michigan, Neurosci Program, Ann Arbor, MI 48109 USA Univ Michigan Ann Arbor MI USA 48109 sci Program, Ann Arbor, MI 48109 USA
Titolo Testata:
TRENDS IN NEUROSCIENCES
fascicolo: 12, volume: 22, anno: 1999,
pagine: 561 - 567
SICI:
0166-2236(199912)22:12<561:LPITAA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
VISUAL CONDITIONED-STIMULI; MEDIAL GENICULATE-BODY; BASOLATERAL AMYGDALA; SYNAPTIC PLASTICITY; LATERAL NUCLEUS; RETROGRADE-AMNESIA; TEMPORAL GRADIENT; STARTLE PARADIGM; NMDA RECEPTORS; NEUROTOXIC LESIONS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Maren, S Univ Michigan, Dept Psychol, 580 Union Dr, Ann Arbor, MI 48109 USA Univ Michigan 580 Union Dr Ann Arbor MI USA 48109 r, MI 48109 USA
Citazione:
S. Maren, "Long-term potentiation in the amygdala: a mechanism for emotional learningand memory", TRENDS NEUR, 22(12), 1999, pp. 561-567

Abstract

In the mammalian brain, LTP is an enduring form of synaptic plasticity that is posited to have a role in learning and memory. Compelling new evidencefor this view derives from studies of LTP in the amygdala, a brain structure that is essential for simple forms of emotional learning and memory, such as Pavlovian fear conditioning in rats. More specifically, antagonists ofthe NMDA receptor block both amygdaloid LTP induction and fear conditioning, fear conditioning induces increases in-amygdaloid synaptic transmission that resemble LTP, and genetic modifications that disrupt amygdaloid LTP eliminate fear conditioning. Collectively, these results provide the most-convincing evidence to date that LTP mediates learning and memory in mammals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 14:29:08