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Titolo:
Lack of normal pattern of cerebral asymmetry in familial schizophrenic patients and their relatives - The Maudsley Family Study
Autore:
Sharma, T; Lancaster, E; Sigmundsson, T; Lewis, S; Takei, N; Gurling, H; Barta, P; Pearlson, G; Murray, R;
Indirizzi:
Inst Psychiat, Dept Psychol Med, Sect Cognit Psychopharmacol, London SE5 8AF, England Inst Psychiat London England SE5 8AF opharmacol, London SE5 8AF, England Johns Hopkins Univ, Dept Psychiat, Div Psychiat Neuroimaging, Baltimore, MD 21287 USA Johns Hopkins Univ Baltimore MD USA 21287 maging, Baltimore, MD 21287 USA Johns Hopkins Univ, Dept Behav Sci, Baltimore, MD 21287 USA Johns Hopkins Univ Baltimore MD USA 21287 av Sci, Baltimore, MD 21287 USA Withington Hosp, Dept Psychiat, Sch Psychiat & Behav Sci, Manchester M20 8LR, Lancs, England Withington Hosp Manchester Lancs England M20 8LR M20 8LR, Lancs, England Hamamatsu Univ, Sch Med, Dept Psychiat & Neurol, Hamamatsu, Shizuoka 4313192, Japan Hamamatsu Univ Hamamatsu Shizuoka Japan 4313192 , Shizuoka 4313192, Japan Royal Free & Univ Coll, Sch Med, Windeyer Inst Med Sci, Dept Psychiat & Behav Sci,Mol Psychiat Lab, London W1P 6DB, England Royal Free & Univ Coll London England W1P 6DB b, London W1P 6DB, England
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 2, volume: 40, anno: 1999,
pagine: 111 - 120
SICI:
0920-9964(19991130)40:2<111:LONPOC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEMISPHERIC ASYMMETRIES; COMPUTED-TOMOGRAPHY; PLANUM TEMPORALE; HUMAN-BRAIN; SCANS; METAANALYSIS; REVERSAL; LANGUAGE; DYSLEXIA; SUBGROUP;
Keywords:
cerebral asymmetry; familial; genetic; magnetic resonance imaging; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Sharma, T Inst Psychiat, Dept Psychol Med, Sect Cognit Psychopharmacol, DeCrespignyPk, London SE5 8AF, England Inst Psychiat De Crespigny Pk LondonEngland SE5 8AF F, England
Citazione:
T. Sharma et al., "Lack of normal pattern of cerebral asymmetry in familial schizophrenic patients and their relatives - The Maudsley Family Study", SCHIZOPHR R, 40(2), 1999, pp. 111-120

Abstract

Lack of the normal cerebral asymmetry has been reported in schizophrenia. We wished to test the hypothesis that this lack of the normal pattern of asymmetry is familial and that it can be found in both schizophrenic and nonschizophrenic family members. In particular, we wanted to know whether thoserelatives who appear to be transmitting liability to the illness also demonstrate the loss of normal asymmetry. We studied families with several members affected with schizophrenia. We carried out volumetric measurements of prefrontal, premotor, sensorimotor and occipitoparietal regions in each hemisphere using 3D reconstructed MRI images in 29 schizophrenic patients, 55 of their first degree relatives, and 39 unrelated control subjects on contiguous thin slices of the brain. Nine of the unaffected relatives appeared to be transmitting the liability for schizophrenia (e.g. the mother of a schizophrenic patient who, although not psychotic herself, had a schizophrenicparent or sibling). We termed them presumed obligate carriers and the remaining 46 relatives presumed non-obligate carriers. The healthy control subjects showed larger right than left prefrontal regions and larger left than right sensorimotor and occipitoparietal regions. The schizophrenic patientsshowed lack of this normal brain asymmetry in the prefrontal, sensorimotorand occipitoparietal cortical regions. The presumed obligate carriers weresimilar to the schizophrenic patients in exhibiting lack of asymmetries inthese cortical regions, while the presumed non-obligate relatives showed lack of asymmetry only in the occipitoparietal region, There was no overall reduction in total or regional brain volumes among the groups. Our findingsindicate that lack of the normal pattern of frontal and occipital asymmetry is a marker for genetic liability to schizophrenia in families multiply affected with schizophrenia. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:45:48