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Titolo:
CSF5-HIAA and aggression in female macaque monkeys: species and interindividual differences
Autore:
Westergaard, GC; Suomi, SJ; Higley, JD; Mehlman, PT;
Indirizzi:
LABS Virginia Inc, Div Res, Yemassee, SC 29945 USA LABS Virginia Inc Yemassee SC USA 29945 , Div Res, Yemassee, SC 29945 USA NICHHD, Lab Comparat Ethol, Anim Ctr, NIH, Poolesville, MD 20837 USA NICHHD Poolesville MD USA 20837 Anim Ctr, NIH, Poolesville, MD 20837 USA NIAAA, Clin Studies Lab, Anim Ctr, NIH, Poolesville, MD 20837 USA NIAAA Poolesville MD USA 20837 , Anim Ctr, NIH, Poolesville, MD 20837 USA
Titolo Testata:
PSYCHOPHARMACOLOGY
fascicolo: 4, volume: 146, anno: 1999,
pagine: 440 - 446
Fonte:
ISI
Lingua:
ENG
Soggetto:
5-HYDROXYINDOLEACETIC ACID CONCENTRATIONS; CEREBROSPINAL-FLUID MONOAMINE; NONHUMAN PRIMATE MODEL; DIMINISHED SOCIAL COMPETENCE; MALE VERVET MONKEYS; AMINE METABOLITES; VIOLENT OFFENDERS; FIRE SETTERS; CSF 5-HIAA; SEROTONERGIC ACTIVITY;
Keywords:
aggression; female; impulsivity; primates; serotonin; social dominance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Westergaard, GC LABS Virginia Inc, Div Res, 95 Castle Hall Rd,POB 557, Yemassee, SC 29945 USA LABS Virginia Inc 95 Castle Hall Rd,POB 557 Yemassee SCUSA 29945
Citazione:
G.C. Westergaard et al., "CSF5-HIAA and aggression in female macaque monkeys: species and interindividual differences", PSYCHOPHAR, 146(4), 1999, pp. 440-446

Abstract

Rationale: While the relationship among CSF 5-HIAA, impulsivity, and aggression is well characterized in males, its investigation in females is limited, and no studies have assessed its generalizability across primates by making simultaneous comparisons between and within closely-related species. Objectives: We tested three hypotheses. First, that female rhesus macaques would have lower CSF 5-HIAA concentrations and be more aggressive than wouldfemale pigtailed macaques. Second, that females of both macaque species would exhibit an inverse relationship between interindividual differences in CSF 5-HIAA concentrations and rates of severe aggression. Third, that subjects with high CSF 5-HIAA concentrations would be higher in social dominancewithin their respective groups than would subjects with low CSF 5-HIAA concentrations. Methods: We obtained CSF samples from 61 individually housed female primates of two closely related species: rhesus macaques (Macaca mulatta) and pigtailed macaques (Macaca nemestrina). We later placed subjects in unisex social groups, and correlated interindividual differences in CSF 5-HIAA with aggression, wounding, and acquisition of social dominance rank, Results: Between-species analyses indicated higher CSF 5-HIAA concentrations in pig-tailed macaques, and higher rates of high-intensity aggression, escalated aggression, and wounds requiring medical treatment in rhesus macaques. Within-species analyses indicated that interindividual differences in CSF 5-HIAA concentrations were inversely correlated with escalated aggression and positively correlated with social dominance rank. Conclusions: These findings show that agonistic and social differences between closely-relatedspecies are correlated with CNS serotonin activity, as species that show relatively high rates of severe aggression also tend to have low concentrations of CSF 5-HIAA. We conclude that serotonergic functioning plays an important role in controlling impulses that regulate severe aggression and social dominance relationships in both male and female primates, and that between-species differences in agonistic temperament can be predicted by species typical CNS serotonin functioning.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 12:43:26