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Titolo:
[I-123]Iomazenil SPECT benzodiazepine receptor imaging in schizophrenia
Autore:
Verhoeff, NPLG; Soares, JC; DSouza, CD; Gil, R; Degen, K; Abi-Dargham, A; Zoghbi, SS; Fujita, M; Rajeevan, N; Seibyl, JP; Krystal, JH; van Dyck, CH; Charney, DS; Innis, RB;
Indirizzi:
Yale Univ, Sch Med, Div Neurochem Brain Imaging, Dept Psychiat, W Haven, CT 06516 USA Yale Univ W Haven CT USA 06516 ging, Dept Psychiat, W Haven, CT 06516 USA VA Connecticut Hlth Care Syst, W Haven, CT 06516 USA VA Connecticut Hlth Care Syst W Haven CT USA 06516 W Haven, CT 06516 USA Columbia Univ Coll Phys & Surg, Dept Psychiat, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Yale Univ, Sch Med, Dept Diagnost Radiol, New Haven, CT USA Yale Univ NewHaven CT USA Med, Dept Diagnost Radiol, New Haven, CT USA VA Connecticut Hlth Care Syst, W Haven, CT USA VA Connecticut Hlth Care Syst W Haven CT USA Care Syst, W Haven, CT USA Yale Univ, Sch Med, Dept Pharmacol, New Haven, CT 06510 USA Yale Univ NewHaven CT USA 06510 Dept Pharmacol, New Haven, CT 06510 USA
Titolo Testata:
PSYCHIATRY RESEARCH-NEUROIMAGING
fascicolo: 3, volume: 91, anno: 1999,
pagine: 163 - 173
SICI:
0925-4927(19991011)91:3<163:[SBRII>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC-ACID; I-123 IOMAZENIL SPET; CEREBRAL BLOOD-FLOW; GABA UPTAKE SITES; PREFRONTAL CORTEX; HIPPOCAMPAL-FORMATION; CINGULATE CORTEX; GENE-EXPRESSION; BRAIN; BINDING;
Keywords:
GABA; psychosis; positive symptoms; negative symptoms; thought disorganization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Verhoeff, NPLG Yale Univ, Sch Med, Div Neurochem Brain Imaging, Dept Psychiat, 950 Campbell Ave, W Haven, CT 06516 USA Yale Univ 950 Campbell Ave W Haven CT USA 06516 T 06516 USA
Citazione:
N.P.L.G. Verhoeff et al., "[I-123]Iomazenil SPECT benzodiazepine receptor imaging in schizophrenia", PSYCH RES-N, 91(3), 1999, pp. 163-173

Abstract

Deficient inhibitory neurotransmission of gamma-aminobutyric acid (GABA) has been implicated in the pathophysiology of schizophrenia based on postmortem studies. However, in vivo studies have shown predominantly negative or conflicting results. The goal of this study was to better characterize possible changes of the regional GABA(A)-benzodiazepine receptor distribution volume (BZR V-3-p) in schizophrenia in vivo, using a larger sample size thanprevious studies. Single photon emission computed tomography (SPECT) with [I-123]iomazenil was used with a constant infusion paradigm to measure the BZR V-3-p under sustained radiotracer equilibrium conditions. Twenty-five patients with schizophrenia and 24 matched healthy control subjects were studied. Positive and Negative Syndrome Scale (PANSS) ratings were done in allsubjects. Statistical parametric mapping (SPM) 96 was used to compare patients and control subjects as well as to study the relationship between SPECT results and composite PANSS scores based on two factorial models: the pentagonal model (positive, negative, dysphoric mood, activation, and autisticpreoccupation factors) and the taxometric model (disorganized dimension). On the basis of 'absolute' values of V-3-p with no normalization for total brain uptake, the schizophrenic patients showed no signficant differences in BZR levels compared to the healthy control subjects. With a global normalization procedure, which is more sensitive to relative regional differencesin activity, BZR V-3-p was significantly decreased in the patients in the left precentral gyrus (BA 6). The relative BZR V-3-p showed a significant positive correlation with duration of illness in the superior occipital gyri(BA 19). No significant correlations were observed between either absoluteor relative BZR V-3-p and either age or any of the composite PANSS scores based on any of the two factorial models in either patients or control subjects. No significant differences were observed between cigarette smoking vs. nan-smoking patients, nor between the patients on atypical antipsychoticsvs, on typical antipsychotics vs. not on any antipsychotics. In general, no significant differences in BZR V-3-p were observed between patients and control subjects, except for a decrease in relative BZR V-3-p in the left precentral gyrus. Grey matter atrophy is unlikely to be the cause for this decrease. However, we could not exclude that possibility. The positive correlation with duration of illness might reflect the relative preservation of neurons expressing BZR in the superior occipital gyri as compared to other cortical brain regions in schizophrenia. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 24/01/20 alle ore 12:49:11