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Titolo:
The effect of novel antipsychotics in rat oral dyskinesia
Autore:
Rosengarten, H; Schweitzer, JW; Friedhoff, AJ;
Indirizzi:
NYU, Sch Med, Dept Psychiat, Millhauser Labs, New York, NY 10016 USA NYU New York NY USA 10016 ychiat, Millhauser Labs, New York, NY 10016 USA
Titolo Testata:
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
fascicolo: 8, volume: 23, anno: 1999,
pagine: 1389 - 1404
SICI:
0278-5846(199911)23:8<1389:TEONAI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
VACUOUS CHEWING MOVEMENTS; NEONATAL 6-OHDA-LESIONED RATS; IN-VIVO DOPAMINE-D-2; TARDIVE-DYSKINESIA; NEUROLEPTIC TREATMENT; RECEPTOR OCCUPANCY; XENOPUS OOCYTES; JAW MOVEMENTS; DOUBLE-BLIND; RISPERIDONE;
Keywords:
D-1 receptor-mediated oral behavior; 5HT-(2C) receptor mediated oral behavior;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Rosengarten, H NYU, Sch Med, Dept Psychiat, Millhauser Labs, 550 1st Ave, New York, NY 10016 USA NYU 550 1st Ave New York NY USA 10016 ew York, NY 10016 USA
Citazione:
H. Rosengarten et al., "The effect of novel antipsychotics in rat oral dyskinesia", PROG NEUR-P, 23(8), 1999, pp. 1389-1404

Abstract

1. The effect of the D1 agonist SKF38393 and the 5HT(2) C agonist m-CPP onrepetitive jaw movements (RJM) was studied in rats. Acute administration of SKF38393 and/or m-CPP induced RJM in a dose dependent manner. In rats treated with both drugs, RJM responses were about equal to the sum of those obtained with each drug alone.2. The induction of RJM by SKF38393 was somewhat lower in rats pretreated with 5HT(2)C receptor antagonist, mianserin, whereas mianserin severely reduced RJM induced by m-CPP alone.3. D1 antagonist SCH23390 inhibited SKF38393 induced RJM but had no effecton m-CPP induced chewing behavior.4. The present study confirms earlier evidence that D1 agonists used at optimal doses for the induction of RJM do not involve the serotonergic systemin a significant way. It does, however, implicate the system in the emergence of drug induced oral behavior in rats.5. The effect of the atypical antipsychotics, clozapine, olanzapine and risperidone was studied on SKF38393 and m-CPP induced RJM. Pretreatment with the atypical antipsychotics clozapine and olanzapine inhibit SKF38393 and m-CPP induced RJM. Pretreatment with risperidone inhibits m- CPP induced oral behavior in rats while increases dose dependently SKF38393 induced RJM.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 21:45:18