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Titolo:
Pulmonary atypical mycobacterial infection in a child with severe combinedimmune deficiency
Autore:
Shames, RS; Cowan, MJ; Umetsu, DT;
Indirizzi:
Stanford Univ, Med Ctr, Dept Pediat, Div Clin Immunol & Allergy,Sch Med, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 lergy,Sch Med, Stanford, CA 94305 USA
Titolo Testata:
PEDIATRIC ASTHMA ALLERGY & IMMUNOLOGY
fascicolo: 2, volume: 13, anno: 1999,
pagine: 79 - 85
SICI:
0883-1874(199922)13:2<79:PAMIIA>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACQUIRED-IMMUNODEFICIENCY-SYNDROME; AVIUM COMPLEX INFECTION; BONE-MARROW TRANSPLANTATION; INTRACELLULARE; AIDS; TUBERCULOSIS; DISEASE; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Shames, RS Stanford Univ, Med Ctr, Dept Pediat, Div Clin Immunol & Allergy,Sch Med, Room G309, Stanford, CA 94305 USA Stanford Univ Room G309 Stanford CA USA 94305 ord, CA 94305 USA
Citazione:
R.S. Shames et al., "Pulmonary atypical mycobacterial infection in a child with severe combinedimmune deficiency", PED ASTHMA, 13(2), 1999, pp. 79-85

Abstract

Mycobacterium avium intracellulare (MAI) infection has not been reported in patients with severe combined immunodeficiency (SCID) prior to immune reconstitution despite the predisposition to opportunistic infection and defective cell mediated immunity in these patients. We report a case of an infant with X-linked SCID (interleukin- [IL-2] receptor gamma chain defect), whoat age 9 months developed fever, hypoxia, and worsening bilateral pulmonary infiltrates 2 days after receipt of a maternal graft of cytokine-mobilized peripheral blood stem cells enriched for CD34(+) cells and depleted of CD3(+) cells. Bronchoalveolar lavage (BAL) specimen was positive on acid-fastbacilli (AFB) culture by radiometric method, and DNA probe confirmed the presence of MAI. After 4 months of treatment with azithromycin, rifabutin, and ethambutol, the patient had radiographic and clinical improvement and negative BAL for AFB by smear and culture. SCID patients with prolonged lowerrespiratory symptoms, hypoxia, abnormal radiographs, failure to isolate specific pathogens, and poor response to standard antimicrobial regimens should be evaluated for infection with MAI.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 08:24:30