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Titolo:
Primary low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma with polypoid appearance. Polypoid gastric MALT lymphoma: A clinicopathologic study of eight cases
Autore:
Yokoi, T; Nakamura, T; Kasugai, K; Yatabe, Y; Fujita, M; Kuroda, M; Akaza, K; Nomura, C; Hamajima, E; Suchi, T; Seto, M; Hara, K; Nakamura, S;
Indirizzi:
Aichi Med Univ Hosp, Div Pathol, Aichi, Japan Aichi Med Univ Hosp Aichi Japan Med Univ Hosp, Div Pathol, Aichi, Japan Aichi Canc Ctr Hosp, Dept Gastroenterol, Nagoya, Aichi 464, Japan Aichi Canc Ctr Hosp Nagoya Aichi Japan 464 erol, Nagoya, Aichi 464, Japan Aichi Med Univ Hosp, Dept Gastroenterol, Aichi, Japan Aichi Med Univ HospAichi Japan Hosp, Dept Gastroenterol, Aichi, Japan Aichi Canc Ctr Hosp, Dept Pathol, Nagoya, Aichi 464, Japan Aichi Canc Ctr Hosp Nagoya Aichi Japan 464 thol, Nagoya, Aichi 464, Japan Aichi Canc Ctr Hosp, Clin Labs, Nagoya, Aichi 464, Japan Aichi Canc Ctr Hosp Nagoya Aichi Japan 464 Labs, Nagoya, Aichi 464, Japan Sapporo Natl Hosp, Dept Pathol, Nagoya, Aichi, Japan Sapporo Natl Hosp Nagoya Aichi Japan , Dept Pathol, Nagoya, Aichi, Japan Fujita Hlth Univ, Sch Med, Dept Pathol 1, Nagoya, Aichi, Japan Fujita HlthUniv Nagoya Aichi Japan Dept Pathol 1, Nagoya, Aichi, Japan Fujita Hlth Univ, Sch Med, Dept Gastroenterol, Nagoya, Aichi, Japan FujitaHlth Univ Nagoya Aichi Japan Gastroenterol, Nagoya, Aichi, Japan Kariya Gen Hosp, Dept Gastroenterol, Nagoya, Aichi, Japan Kariya Gen HospNagoya Aichi Japan t Gastroenterol, Nagoya, Aichi, Japan Aichi Canc Ctr, Res Inst, Lab Chemotherapy, Nagoya, Aichi 464, Japan AichiCanc Ctr Nagoya Aichi Japan 464 motherapy, Nagoya, Aichi 464, Japan
Titolo Testata:
PATHOLOGY INTERNATIONAL
fascicolo: 8, volume: 49, anno: 1999,
pagine: 702 - 709
SICI:
1320-5463(199908)49:8<702:PLGMLT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
HELICOBACTER-PYLORI INFECTION; NON-HODGKINS-LYMPHOMAS; B-CELL LYMPHOMA; STAGING CLASSIFICATION; REGRESSION; ERADICATION; DISEASE; CURE;
Keywords:
eradication; Helicobacter pylori; mucosa-associated lymphoid tissue lymphoma; polypoid; stomach;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Yokoi, T Aichi Med Univ Hosp, Div Pathol, Nagakute Cho, Aichi, Japan AichiMed Univ Hosp Nagakute Cho Aichi Japan Cho, Aichi, Japan
Citazione:
T. Yokoi et al., "Primary low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma with polypoid appearance. Polypoid gastric MALT lymphoma: A clinicopathologic study of eight cases", PATHOL INT, 49(8), 1999, pp. 702-709

Abstract

In the current study, we report eight cases with primary low-grade gastricmucosa-associated lymphoid tissue (MALT) lymphoma endoscopically characterized by polypoid lesions in order to highlight their clinicopathologic significance. Four patients were male, their ages ranging from 40 to 78 years old. The resected specimens revealed a histology of low-grade MALT lymphoma characterized by dense lymphocytic infiltration predominantly in the submucosa and a relatively monotonous proliferation of centrocyte-like cells withreactive follicles and infrequent lymphoepithelial lesions. The tumor cells were of CD5(-), CD10(-), CD20(+), BCL2(+) and cycline D1(-) phenotype, and showed a monoclonal rearrangement of immunoglobulin heavy chain genes in the five of six cases examined. Interestingly, Helicobacter pylori (H. pylori) was detected in three (37.5%) of the eight patients, which was significantly tower than previous reports. Two of the H. pylori-positive cases initially underwent H. pylori eradication, but showed no change In their lymphomas after the cure of H. pylori infection. The clinicopathologic findings of the present cases appeared to closely resemble those of colorectal MALT lymphoma with a polypoid appearance and few association of H. pylori Infection in their pathogenesis. These gastric polypoid cases may merit separate; consideration because of the therapeutic problems they pose.

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Documento generato il 01/12/20 alle ore 07:11:12