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Titolo:
Molecular-pathological diagnosis of gastrointestinal tissues and its contribution to cancer histopathology
Autore:
Yasui, W; Yokozaki, H; Shimamoto, F; Tahara, H; Tahara, E;
Indirizzi:
Hiroshima Univ, Sch Med, Dept Pathol 1, Minami Ku, Hiroshima 7348551, Japan Hiroshima Univ Hiroshima Japan 7348551 nami Ku, Hiroshima 7348551, Japan Hiroshima Univ Hosp, Dept Pathol, Hiroshima, Japan Hiroshima Univ Hosp Hiroshima Japan Hosp, Dept Pathol, Hiroshima, Japan Hiroshima Univ, Sch Med, Dept Cellular & Mol Biol, Hiroshima, Japan Hiroshima Univ Hiroshima Japan pt Cellular & Mol Biol, Hiroshima, Japan
Titolo Testata:
PATHOLOGY INTERNATIONAL
fascicolo: 9, volume: 49, anno: 1999,
pagine: 763 - 774
SICI:
1320-5463(199909)49:9<763:MDOGTA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
GERM-LINE MUTATIONS; COLORECTAL-CANCER; TELOMERASE ACTIVITY; MICROSATELLITE INSTABILITY; HISTONE DEACETYLASE; GASTRIC CARCINOMAS; EXPRESSION; PROTEIN; CELLS; ADENOCARCINOMAS;
Keywords:
gastrointestinal carcinoma; genetic alteration; molecular-pathological diagnosis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Yasui, W Hiroshima Univ, Sch Med, Dept Pathol 1, Minami Ku, 1-2-3 Kasumi, Hiroshima7348551, Japan Hiroshima Univ 1-2-3 Kasumi Hiroshima Japan 7348551 48551, Japan
Citazione:
W. Yasui et al., "Molecular-pathological diagnosis of gastrointestinal tissues and its contribution to cancer histopathology", PATHOL INT, 49(9), 1999, pp. 763-774

Abstract

Multiple genetic and epigenetic alterations of cancer-related genes and molecules are involved in the course of the development and progression of gastrointestinal cancers. These include telomerase activation, genetic instability, and abnormalities of oncogenes, tumor suppressor genes, cell cycle regulators, cell adhesion molecules and DNA repair genes. By analyzing thesealterations in pathology specimens, we can improve differential diagnosis of cancer, obtain information of grade of malignancy, and identify patientsat high risk for developing multiple primary cancers. Since 1993, a systemof molecular-pathological diagnosis was established, and has been performed as a routine service in collaboration with Hiroshima City Medical Association Clinical Laboratory. More than 10 000 cases of gastrointestinal biopsyand surgery have been analyzed, and additional information of differentialdiagnosis, biological malignancy and tumor multiplicity could be obtained. Molecular-pathological diagnosis may provide a new approach to cancer diagnosis and novel therapeutics for the 21st century. Furthermore, the analysis of the genetic and epigenetic abnormalities in clinical materials may clarify the molecular mechanism of carcinogenesis and comparative morphological changes. From the analyses of p27(KIP1) and telomerase in gastrointestinal adenomas, we have learned that morphological abnormality of the nucleus is an indicator for cells with immortality and malignant potential that mustparticipate in super-early diagnosis (detection of true precancerous lesions) of gastrointestinal cancer. Molecular-pathological diagnosis thus contributes to detailed understanding of cancer histopathology and improves the histopathological diagnosis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 18:36:05