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Titolo:
Parenterally administered kainic acid induces a persistent hyperalgesia inthe mouse and rat
Autore:
Giovengo, SL; Kitto, KF; Kurtz, HJ; Velazquez, RA; Larson, AA;
Indirizzi:
Univ Minnesota, Dept Vet Pathobiol, St Paul, MN 55108 USA Univ Minnesota St Paul MN USA 55108 Vet Pathobiol, St Paul, MN 55108 USA Univ Minnesota, Dept Diagnost Invest, St Paul, MN 55108 USA Univ Minnesota St Paul MN USA 55108 iagnost Invest, St Paul, MN 55108 USA Univ Minnesota, Grad Program Neurosci, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 urosci, Minneapolis, MN 55455 USA
Titolo Testata:
PAIN
fascicolo: 2, volume: 83, anno: 1999,
pagine: 347 - 358
SICI:
0304-3959(199911)83:2<347:PAKAIA>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCITATORY AMINO-ACIDS; SCIATIC-NERVE INJURY; D-ASPARTATE NMDA; SPINAL-CORD; SUBSTANCE-P; DORSAL HORN; RECEPTOR ANTAGONISTS; DRG NEURONS; GLUTAMATE; AFFERENT;
Keywords:
kainic acid; hyperalgesia; spinal cord; primary afferent fibers; nociception; dorsal root ganglia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Larson, AA Univ Minnesota, Dept Vet Pathobiol, 295 AnSci VetMed Bldg,1988 Fitch Ave, St Paul, MN 55108 USA Univ Minnesota 295 AnSci VetMed Bldg,1988 Fitch Ave St Paul MN USA 55108
Citazione:
S.L. Giovengo et al., "Parenterally administered kainic acid induces a persistent hyperalgesia inthe mouse and rat", PAIN, 83(2), 1999, pp. 347-358

Abstract

Nociceptive primary afferent C-fibers express a subset of glutamate receptors that are sensitive to kainic acid. Thus, we tested the possibility thatactivation of these receptors alters nociception. Intraperitoneal (i.p.) injection of kainic acid induced a persistent thermal hyperalgesia, when tested using the hot plate (mice) and tail flick (mice and rats) assays, and mechanical hyperalgesia when tested using von Frey monofilaments (rats), buthad no effect on acetic acid-induced chemical nociception (mice). When administered i.p., 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), an (R,S)-alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionic acid HBr/kainate (AMPA/KA) antagonist, completely blocked hyperalgesia. When injected intrathecally (i.t.), kainic acid itself failed to induce hyperalgesia and AMPA/KA antagonists given i.t. also failed to attenuate the hyperalgesic effect of kainic acid administered i.p., indicating that the spinal cord is not the primary site of action. Kainic acid injected subcutaneously in the back of mice decreased response latencies in the hot plate and tail flick assays, indicatingthat hyperalgesia is achieved by a variety of parenteral routes of injection. Histological evaluation of rat spinal cord and dorsal root ganglia revealed no neurodegenerative changes 24 h after kainic acid. Together these data suggest that a persistent hyperalgesia results from the transient activation of AMPA/KA receptors that are located outside the spinal cord, perhapson the distal projections of primary afferent fibers. (C) 1999 International Association for the Study of Pain. Published by Elsevier Science B.V.

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Documento generato il 30/11/20 alle ore 03:30:53