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Titolo:
Synthesis of radioiodinated 1-deoxy-nojirimycin derivatives: Novel glucoseanalogs
Autore:
Xu, YM; Choi, SR; Kung, MP; Kung, HF;
Indirizzi:
Univ Penn, Dept Radiol, Philadelphia, PA 19104 USA Univ Penn PhiladelphiaPA USA 19104 pt Radiol, Philadelphia, PA 19104 USA Univ Penn, Dept Pharmacol, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Pharmacol, Philadelphia, PA 19104 USA
Titolo Testata:
NUCLEAR MEDICINE AND BIOLOGY
fascicolo: 7, volume: 26, anno: 1999,
pagine: 833 - 839
SICI:
0969-8051(199910)26:7<833:SOR1DN>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUGAR N-BUTYLDEOXYNOJIRIMYCIN; GLYCOLIPID BIOSYNTHESIS; CONFORMATIONAL BASIS; INHIBITION; (+)-NOJIRIMYCIN; GLYCOSIDASES;
Keywords:
brain; tumor imaging agents; glucose metabolism; radioiodination;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Kung, HF Univ Penn, Dept Radiol, 3700 Market St,Room 305, Philadelphia, PA19104 USA Univ Penn 3700 Market St,Room 305 Philadelphia PA USA 19104 4 USA
Citazione:
Y.M. Xu et al., "Synthesis of radioiodinated 1-deoxy-nojirimycin derivatives: Novel glucoseanalogs", NUCL MED BI, 26(7), 1999, pp. 833-839

Abstract

Novel lipophilic and neutral glucose analogs, which are potentially usefulfor tumor imaging, have been developed. They are designed to circumvent Glut-facilitated transport mechanism, and direct the localization by either hexokinase binding or enzyme reactions (phosphorylation) as potential metabolic markers of tumor cells. Syntheses of tetraacetylated N-(3'-iodo-2'-propenyl)-1-deoxy-nojirimycin (11) and N-(3'-iodo-benzyl)-1-deoxy-nojirimycin (14) were achieved by reacting 1-deoxy-nojirimycin with appropriate alkylating agents. The corresponding tri-butyltin derivatives were also prepared asthe starting materials for preparation of I-125-labeled compounds for biodistribution study in rats. Biodistribution in rats showed that [I-123]14 exhibited a modest initial brain uptake and retention at a later time (0.59, 0.38, 0.30, and 0.30% dose/organ at 2, 30, 60, and 120 min after an intravenous [IV] injection, respectively), whereas [I-125]11 displayed a lower brain uptake (0.35, 0.27, 0.20, and 0.18% dose/organ at 2, 30, 60, and 120 min). In addition, compounds with free hydroxyl groups (12 and 13) were also obtained. As expected, after an IV injection, these free hydroxyl compounds showed a dramatic decrease in brain uptake in rats. It appears that both ofthe acetylated agents (11 and 14) which display higher lipophilicity (partition coefficient [P.C.] = 57.9 and 1,462, respectively), can penetrate thebrood-brain barrier (BBB) by a simple diffusion mechanism whereas the freehydroxy compounds (12 and 13), with lower lipophilicity (P.C. = 0.43 and 6.8), showed no brain uptake. A similar pair of glucose derivatives, fluorodeoxyglucose (FDG) and tetraacetylated FDG (AFDG), displayed a dramatic difference in brain uptake in rats. While the lipophilic AFDG (P.C. = 3.79) maypenetrate the intact BBB, due to its relatively low P.C. value, the first pass extraction due to simple diffusion mechanism may be low (brain uptake at 2 min was 0.68% dose/organ). The FDG itself has a very low lipophilicity(P.C. = 0.22) but it can be taken up into the brain by a glucose transporter mediated mechanism to cross the BBB (brain uptake at 2 min was 2.53% dose/organ). Preliminary data of these glucose derivatives suggest that further studies are needed to elucidate the uptake and retention mechanisms and their potential application as tumor imaging agents. NUCL MED BIOL 26;7:833-839, 1999. (C) 1999 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 19:13:32