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Titolo:
Biochemical evaluation of bone metabolism in dialysis patients
Autore:
Van Hoof, VO; Couttenye, MM; Van Brussel, KA; Wendelen, LC; Waegemans, SE; De Broe, ME;
Indirizzi:
Univ Antwerp Hosp, Dept Clin Chem, B-2650 Edegem, Belgium Univ Antwerp Hosp Edegem Belgium B-2650 lin Chem, B-2650 Edegem, Belgium Univ Antwerp Hosp, Dept Nephrol Hypertens, B-2650 Edegem, Belgium Univ Antwerp Hosp Edegem Belgium B-2650 ypertens, B-2650 Edegem, Belgium
Titolo Testata:
NIEREN-UND HOCHDRUCKKRANKHEITEN
fascicolo: 10, volume: 28, anno: 1999,
pagine: 402 - 406
SICI:
0300-5224(199910)28:10<402:BEOBMI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALKALINE-PHOSPHATASE ISOENZYMES; PYRIDINIUM CROSS-LINKS; HEMODIALYSIS-PATIENTS; VERTEBRAL OSTEOPOROSIS; SERUM; COLLAGEN; TURNOVER; DISEASE; PYRIDINOLINE; EXCRETION;
Keywords:
pyridinoline crosslinks; bone alkaline phosphatase; dialysis; bone metabolism; HPLC;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Van Hoof, VO Univ Antwerp Hosp, Dept Clin Chem, Wilrijkstr 10, B-2650 Edegem, Belgium Univ Antwerp Hosp Wilrijkstr 10 Edegem Belgium B-2650 elgium
Citazione:
V.O. Van Hoof et al., "Biochemical evaluation of bone metabolism in dialysis patients", NIEREN HOCH, 28(10), 1999, pp. 402-406

Abstract

Chronic renal failure (CRF) patients are prone to develop bone diseases. Serum bone alkaline phosphatase (BAP) is a good marker for bone formation inthese patients. There is no equivalent serum test to evaluate their bone resorption, but serum pyridinoline (PYD) and deoxypyridinoline (DPYD) crosslinks could be a valid alternative to the urine test? which is not useful inCRF. Bone metabolism was evaluated in 36 dialyzed patients by measuring PYD and DPYD with HPLC, and BAP with electrophoresis at 3 - 5 occasions within a 4- to 9-month interval. PYD ranged from 46 - 1666 nmol/l and DPYD from 6 - 475 nmol/l. Median intra-individual CVs were 13% for PYD, 21% for DPYD and 19% for BAP. DPYD correlated strongly with PYD. PYD, DPYD and BAP correlated negatively with age. PYD and DPYD strongly correlated with BAP. PYD, DPYD and BAP correlated with PTH. BAP < 16 U/l and PTH > 200 ng/l were usedas biochemical criteria for adynamic bone disease (low bone turnover) and secondary hyperparathyroidism (high bone turnover), respectively. Implementation of the values with optimal diagnostic performance (ROC curves) allowed to discriminate between low and high bone turnover in individual dialysispatients.

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Documento generato il 30/11/20 alle ore 17:23:07