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Titolo:
Repair of the damaged brain. The Alfred Meyer Memorial Lecture 1998
Autore:
Dunnett, SB;
Indirizzi:
Univ Cambridge, MRC, Cambridge Ctr Brain Repair, Cambridge CB2 2PY, England Univ Cambridge Cambridge England CB2 2PY air, Cambridge CB2 2PY, England
Titolo Testata:
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
fascicolo: 5, volume: 25, anno: 1999,
pagine: 351 - 362
SICI:
0305-1846(199910)25:5<351:ROTDBT>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRASTRIATAL STRIATAL GRAFTS; EMBRYONIC DOPAMINE NEURONS; PARKINSONS-DISEASE; KAINIC ACID; ADULT-RAT; SUBSTANTIA NIGRA; 6-OHDA LESIONS; BEHAVIORAL RECOVERY; DENERVATED STRIATUM; HUNTINGTONS-CHOREA;
Keywords:
cognitive deficits; functional recovery; Huntington's disease; motor deficits; neural transplantation; nigral grafts; Parkinson's disease; striatal grafts;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
69
Recensione:
Indirizzi per estratti:
Indirizzo: Dunnett, SB Univ Cambridge, MRC, Cambridge Ctr Brain Repair, Forvie Site,Robinson Way,Cambridge CB2 2PY, England Univ Cambridge Forvie Site,Robinson Way Cambridge England CB2 2PY
Citazione:
S.B. Dunnett, "Repair of the damaged brain. The Alfred Meyer Memorial Lecture 1998", NEUROP AP N, 25(5), 1999, pp. 351-362

Abstract

Over the last decade, neural transplantation has progressed from being an experimental technique for studying regeneration and plasticity in the brain to clinical trials of reconstructive surgery in human neurodegenerative disease. Whereas clear evidence is only available at present for the viability of this technique in Parkinson's disease, applications to several other diseases, including Huntington's disease, multiple sclerosis, spinal cord injury, and chronic pain are currently under active consideration. It is clear that the techniques of transplantation can be functionally viable under certain well-defined biological circumstances, but significant problems remain in the availability of suitable donor tissues and defining the optimal conditions for reliable survival of the implanted cells. If we are to obtain improved reliability of the present techniques or identify suitable alternatives, we need a better understanding of the conditions for the survival and integration of grafts into the host brain, and the mechanisms by which they influence host function. In this review I consider the nature of the structural reconstruction required to achieve repair in animal models of Parkinson's and Huntington's diseases, contrasting the replacement of deficient neurochemicals within the striatum in the former case, and the need for reconstruction of input and output connections of the striatal circuitry in the latter.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:21:54