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Titolo:
Serum and CSF neuron-specific enolase in patients with West syndrome
Autore:
Suzuki, Y; Toribe, Y; Goto, M; Kato, T; Futagi, Y;
Indirizzi:
Osaka Med Ctr, Div Pediat Neurol, Osaka 5941101, Japan Osaka Med Ctr Osaka Japan 5941101 iv Pediat Neurol, Osaka 5941101, Japan
Titolo Testata:
NEUROLOGY
fascicolo: 8, volume: 53, anno: 1999,
pagine: 1761 - 1764
SICI:
0028-3878(19991110)53:8<1761:SACNEI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
STATUS EPILEPTICUS; NEUROLOGICAL DISORDERS; CEREBROSPINAL-FLUID; MARKER; INJURY; BLOOD;
Keywords:
infantile spasms; West syndrome; neuron-specific enolase;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Suzuki, Y Osaka Med Ctr, Div Pediat Neurol, 840 Murodo Cho, Osaka 5941101,Japan Osaka Med Ctr 840 Murodo Cho Osaka Japan 5941101 5941101, Japan
Citazione:
Y. Suzuki et al., "Serum and CSF neuron-specific enolase in patients with West syndrome", NEUROLOGY, 53(8), 1999, pp. 1761-1764

Abstract

Objective: To determine whether frequent seizures and/or hypsarrhythmia may cause neuronal injury in West syndrome. Background: West syndrome is an age-related epileptic syndrome of infancy characterized by clusters of epileptic spasms, a peculiar interictal EEG pattern of hypsarrhythmia, and mental deterioration. Recent clinical studies demonstrated that serum and CSF neuron-specific enolase (NSE)-a marker of neuronal injury-were increased after status epilepticus. Methods: The authors examined serum and CSF NSE levels in 18 newly diagnosed infants (8.4 +/- 2.2 months) with West syndrome (3 cryptogenic, 15 symptomatic). In patients who showed complete resolution ofspasms and disappearance of hypsarrhythmia (responders), additional serum NSE levels were determined several weeks after cessation of seizures. SerumNSE levels were obtained from 28 age-matched infants with normal neurologic development (control group), and 10 infants with an acute neurologic insult. Results: There were no significant differences (p > 0.05) in serum NSE levels between the group with West syndrome (12.9 +/- 3.4 ng/mL) and the control group (13.2 +/- 3.1 ng/mL). The serum NSE value in the group with an acute insult (100.3 +/- 67.4 ng/mL) was significantly higher (p < 0.0001) than that for the West syndrome and the control groups. The mean +/- SD CSF NSE level was 7.3 +/- 3.6 ng/mL, which is similar to the reported CSF NSE levels of Japanese infants without neurologic disease. Thirteen responders showed no significant (p > 0.05) change in serum NSE after cessation of epileptic spasms. Conclusion: Normal serum and CSF neuron-specific enolase levels provided no evidence that seizures and/or hypsarrhythmia induced neuronal injury in West syndrome.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:16:17