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Titolo:
Reduced anisotropy of water diffusion in structural cerebral abnormalitiesdemonstrated with diffusion tensor imaging
Autore:
Wieshmann, UC; Clark, CA; Symms, MR; Franconi, F; Barker, GJ; Shorvon, SD;
Indirizzi:
Inst Neurol, NSE Epilepsy Res MRI Unit, Epilepsy Res Grp, London WC1N 3BG,England Inst Neurol London England WC1N 3BG psy Res Grp, London WC1N 3BG,England
Titolo Testata:
MAGNETIC RESONANCE IMAGING
fascicolo: 9, volume: 17, anno: 1999,
pagine: 1269 - 1274
SICI:
0730-725X(199911)17:9<1269:RAOWDI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE; NERVOUS-SYSTEM; BRAIN; STROKE; COEFFICIENTS;
Keywords:
diffusion tensor imaging; anisotropy; cerebral structural abnormalities;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Wieshmann, UC Natl Soc Epilepsy, MRI Unit, Chalfont St Peter, Gerrards Cross SL9 0RJ, Bucks, England Natl Soc Epilepsy Chalfont St Peter Gerrards Cross Bucks England SL9 0RJ
Citazione:
U.C. Wieshmann et al., "Reduced anisotropy of water diffusion in structural cerebral abnormalitiesdemonstrated with diffusion tensor imaging", MAGN RES IM, 17(9), 1999, pp. 1269-1274

Abstract

We used diffusion tensor imaging (DTI) to investigate the behavior of water diffusion in cerebral structural abnormalities. The fractional anisotropy, a measure of directionality of the molecular motion of water, and the mean diffusivity, a measure of the magnitude of the molecular motion of water,were measured in 18 patients with longstanding partial epilepsy and structural abnormalities on standard magnetic resonance imaging and the results compared with measurements in the white matter of 10 control subjects. Structural abnormalities were brain damage (postsurgical brain damage, nonspecific brain damage, perinatal brain damage, perinatal infarct, ischemic infarct, perinatal hypoxia, traumatic brain damage (n = 3), mitochondrial cytopathy and mesiotemporal sclerosis), dysgenesis (cortical dysplasia (n = 2) andheterotopia) and tumors (meningioma (n = 2), hypothalamic hamartoma and glioma). Anisotropy was reduced in all structural abnormalities. In the majority of abnormalities this,vas associated with an increased mean diffusivity; however, 30% of all structural abnormalities (some patients with brain damage and dysgenesis) had a normal mean diffusivity in combination with a reduced anisotropy. There was no correlation between fractional anisotropy and mean diffusivity measurements in structural abnormalities (r = -0.1). Ourfindings suggest that DTI is sensitive for the detection of a variety of structural abnormalities, that a reduced anisotropy is the common denominator in structural cerebral abnormalities of different etiologies and that mean diffusivity and fractional anisotropy may be, in part, independent. Combined measurements of mean diffusivity and fractional anisotropy are likely to increase the specificity of DTI. (C) 1999 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 11:00:59