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Titolo:
Effects of selective dopamine D-4 receptor blockers, NRA0160 and L-745,870, on A9 and A10 dopamine neurons in rats
Autore:
Kawashima, N; Okuyama, S; Omura, T; Chaki, S; Tomisawa, K;
Indirizzi:
Taisho Pharmaceut Co Ltd, Med Res Labs, Lab 1, Omiya, Saitama 3308530, Japan Taisho Pharmaceut Co Ltd Omiya Saitama Japan 3308530 itama 3308530, Japan
Titolo Testata:
LIFE SCIENCES
fascicolo: 24, volume: 65, anno: 1999,
pagine: 2561 - 2571
SICI:
0024-3205(19991105)65:24<2561:EOSDDR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMPHETAMINE-INDUCED INHIBITION; POSITRON-EMISSION-TOMOGRAPHY; NIGRAL FEEDBACK PATHWAY; D4 RECEPTORS; ELECTROPHYSIOLOGICAL PROFILE; PRIMATE BRAIN; HIGH-AFFINITY; ANTAGONIST; SCHIZOPHRENIA; AUTORECEPTORS;
Keywords:
NRA0160; L-745,870; dopamine D-4 receptors; electrophysiology; atypical antipsychotic effects;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Kawashima, N Taisho Pharmaceut Co Ltd, Med Res Labs, Lab 1, 1-403 Yoshino Cho, Omiya, Saitama 3308530, Japan Taisho Pharmaceut Co Ltd 1-403 Yoshino Cho Omiya Saitama Japan 3308530
Citazione:
N. Kawashima et al., "Effects of selective dopamine D-4 receptor blockers, NRA0160 and L-745,870, on A9 and A10 dopamine neurons in rats", LIFE SCI, 65(24), 1999, pp. 2561-2571

Abstract

Extracellular single-unit activities of dopamine neurons were recorded using chloral hydrate anaesthetized rats. We examined the reversal effects of the selective dopamine D-4 receptor blockers, NRA0160 (2-Carbamoyl-4-(4-fluorophenyl)-5-[2-[4-(piperidin-1-yl] ethyl] thiazole) and L-745,870 (3-[[4-(4-chlorophenyl) piperazin-1-yl] methyl]-1H-pyrrolo [2,3-b] pyridine), on dopamine agonists induced inhibition of dopamine neural activity. The firing rates of the substantia nigra pars compacta(A9) and the ventral tegmental area(A10) dopamine neurons were inhibited by methamphetamine (MAP: 1 mg/kg, i.v.) and apomorphine (APO: 40 mu g/kg, i.v.). NRA0160 dose-dependently reversed the inhibitory effects of MAP and APO on both A9 and A10 dopamine neurons. NRA0160 was more potent in reversing the inhibitory effects of both MAP and APO on A10 than A9 dopamine neurons. L-745,870 failed to reverse theinhibition produced by MAP on A9 and A10 dopamine neurons, whereas L-745,870, at the highest dose used, significantly reversed APO-induced inhibitionof A10 but not A9 dopamine neurons. These results suggest that NRA0160 hasdifferent electrophysiological profiles on dopaminergic neural activity compared to L-745,870 and may have atypical antipsychotic effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:46:01