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Titolo:
The regulation of interferon-tau production and uterine hormone receptors during early pregnancy
Autore:
Mann, GE; Lamming, GE; Robinson, RS; Wathes, DC;
Indirizzi:
Univ Nottingham, Sch Biol Sci, Div Anim Physiol, Loughborough LE12 5RD, Leics, England Univ Nottingham Loughborough Leics England LE12 5RD 2 5RD, Leics, England Univ London Royal Vet Coll, Dept Vet Basic Sci, Potters Bar EN6 1NB, Herts, England Univ London Royal Vet Coll Potters Bar Herts England EN6 1NB rts, England
Titolo Testata:
JOURNAL OF REPRODUCTION AND FERTILITY
, , anno: 1999, supplemento:, 54
pagine: 317 - 328
SICI:
0022-4251(1999):<317:TROIPA>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOMETRIAL OXYTOCIN RECEPTORS; OVINE TROPHOBLAST PROTEIN-1; ESTROUS-CYCLE; CORPUS-LUTEUM; CONCEPTUS DEVELOPMENT; BOVINE ENDOMETRIUM; PROGESTERONE TREATMENT; INTRAUTERINE INFUSION; COWS; CATTLE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Mann, GE Univ Nottingham, Sch Biol Sci, Div Anim Physiol, Sutton Bonington, Loughborough LE12 5RD, Leics, England Univ Nottingham Sutton Bonington Loughborough Leics England LE12 5RD
Citazione:
G.E. Mann et al., "The regulation of interferon-tau production and uterine hormone receptors during early pregnancy", J REPR FERT, 1999, pp. 317-328

Abstract

During early pregnancy the bovine embryo must produce a protein called interferon tau which inhibits the development of the luteolytic mechanism. Failure to inhibit luteolysis is the major cause of pregnancy loss in cows. The embryo must produce sufficient quantities of interferon tau by about day 16 to prevent luteolysis. Its ability to achieve this is largely dependent on the pattern of maternal progesterone production. A late rise in progesterone after ovulation or poor progesterone secretion during the luteal phaseresults in the development of poor embryos capable of producing little or no interferon tau at the critical time. The embryo inhibits luteolysis by preventing development of oxytocin receptors on the luminal epithelium of the uterine endometrium and thus oxytocin-induced secretion of PGF(2 alpha) and by the induction of a prostaglandin synthesis inhibitor within the endometrium. In sheep it has been hypothesised that interferon tau acts to inhibit endometrial oestrogen receptors and thus oestrogen-induced upregulation of oxytocin receptors. In cows, the embryo inhibits the development of oxytocin receptors and the initiation of luteolysis without causing any change in uterine oestrogen receptors. Thus in the cow, the mechanism by which interferon tau inhibits oxytocin receptor development remains to be determined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/08/20 alle ore 20:37:16