Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Urinary supersaturation of calcium oxalate and phosphate in patients with X-linked hypophosphatemic rickets and in healthy schoolchildren
Autore:
Patzer, L; vant Hoff, W; Shah, V; Hallson, P; Kasidas, GP; Samuell, C; de Bruyn, R; Barratt, TM; Dillon, MJ;
Indirizzi:
Univ Coll London, Sch Med, Inst Child Hlth, Nephrourol Unit, London WC1N 1EH, England Univ Coll London London England WC1N 1EH Unit, London WC1N 1EH, England Univ Coll London Hosp, Dept Chem Pathol, London, England Univ Coll London Hosp London England Dept Chem Pathol, London, England Great Ormond St Hosp Children, Dept Radiol, London WC1N 3JH, England GreatOrmond St Hosp Children London England WC1N 3JH WC1N 3JH, England
Titolo Testata:
JOURNAL OF PEDIATRICS
fascicolo: 5, volume: 135, anno: 1999,
pagine: 611 - 617
SICI:
0022-3476(199911)135:5<611:USOCOA>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYP MOUSE; PEX GENE; NEPHROCALCINOSIS; CHILDREN; NEPHROLITHIASIS; HYPEROXALURIA; SATURATION; KIDNEYS; MICE; CALCIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Dillon, MJ Univ Coll London, Sch Med, Inst Child Hlth, Nephrourol Unit, 30Guilford St, London WC1N 1EH, England Univ Coll London 30 Guilford St London England WC1N 1EH ngland
Citazione:
L. Patzer et al., "Urinary supersaturation of calcium oxalate and phosphate in patients with X-linked hypophosphatemic rickets and in healthy schoolchildren", J PEDIAT, 135(5), 1999, pp. 611-617

Abstract

Nephrocalcinosis (NC) is a complication of the treatment of X-linked hypophosphatemic rickets (XLHR). Some stud;es have found that treated patients have enteric hyperoxaluria caused by phosphate therapy and have implicated calcium oxalate, whereas others have found only calcium phosphate in renal biopsy tissue. Aim and methods: We aimed to study the urinary supersaturation of calcium oxalate and calcium phosphate and to determine whether these measures are risk factors for NC. We collected 24-hour urine samples from 20 patients (12girls) with XLHR, mean +/- SD age 8.2 +/- 4.7years, and from 79 age-matched members of a healthy control group prospectively. Results: The median 24-hour urine excretions of oxalate, phosphate, and citrate (mmol/1.73 m(2) per day) were significantly increased in patients compared with the control group (oxalate 0.38 vs 0.28, P =.0012; phosphate 63.1 vs 25.8, P <.0001; citrate 4.18 vs 2.7, P =.0002). However, no significant differences were seen in the calcium oxalate or calcium phosphate betweenpatients and the control group. No significant differences were seen in 24-hour urine calcium or magnesium excretion between patients and the controlgroup; however, 8 patients had hypercalciuria. A significant higher urine volume in patients compared with the normal group (826 mL/m(2) 24-hour vs 597 mL/m2 24-hour; P <.005) was found. Twelve patients had NC at the time ofinvestigation and although the oxalate excretion was significantly higher in these patients, no significant difference was seen in the relative supersaturation of calcium oxalate monohydrate (CaC2O4. H2O) compared with the 8without NC. Conclusions: Although 24-hour urine oxalate and phosphate excretion are increased in treated patients with XLHR, there is no increase in the supersaturation of either calcium oxalate or, phosphate. Determination of the supersaturation of calcium oxalate or calcium phosphate does not predict the development of NC in XLHR.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 09:39:23