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Titolo:
Graphical analysis and simplified quantification of striatal and extrastriatal dopamine D-2 receptor binding with [I-123]epidepride SPECT
Autore:
Ichise, M; Fujita, M; Seibyl, JP; Verhoeff, NPLG; Baldwin, RM; Zoghbi, SS; Rajeevan, N; Charney, DS; Innis, RB;
Indirizzi:
Mt Sinai Hosp, Dept Nucl Med, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp Toronto ON Canada M5G 1X5 Med, Toronto, ON M5G 1X5, Canada Univ Toronto, Toronto, ON, Canada Univ Toronto Toronto ON CanadaUniv Toronto, Toronto, ON, Canada Yale Univ, Dept Psychiat, W Haven, CT USA Yale Univ W Haven CT USAYale Univ, Dept Psychiat, W Haven, CT USA Yale Univ, Dept Diagnost Radiol, W Haven, CT USA Yale Univ W Haven CT USA ale Univ, Dept Diagnost Radiol, W Haven, CT USA Yale Univ, Dept Pharmacol, W Haven, CT USA Yale Univ W Haven CT USAYale Univ, Dept Pharmacol, W Haven, CT USA Vet Affairs Connecticut, W Haven, CT USA Vet Affairs Connecticut W Haven CT USA airs Connecticut, W Haven, CT USA
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 11, volume: 40, anno: 1999,
pagine: 1902 - 1912
SICI:
0161-5505(199911)40:11<1902:GAASQO>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN BRAIN; I-125 EPIDEPRIDE; IODINE-123-IBF SPECT; TRANSFER CONSTANTS; D2 RECEPTORS; RADIOLIGANDS; QUANTITATION; METABOLITES; TRACERS; CORTEX;
Keywords:
graphical analysis; [I-123]epidepride; dopamine D-2 receptors; SPECT quantification; metabolite correction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Ichise, M Mt Sinai Hosp, Dept Nucl Med, 600 Univ Ave,Rm 635 Nucl Med, Toronto, ON M5G 1X5, Canada Mt Sinai Hosp 600 Univ Ave,Rm 635 Nucl Med Toronto ON Canada M5G 1X5
Citazione:
M. Ichise et al., "Graphical analysis and simplified quantification of striatal and extrastriatal dopamine D-2 receptor binding with [I-123]epidepride SPECT", J NUCL MED, 40(11), 1999, pp. 1902-1912

Abstract

The purpose of this study was to extend the graphical analysis of reversible tracer binding to account for labeled lipophilic metabolites (metabolites) in quantifying [I-123]epidepride binding to striatal and extrastriatal D-2 receptors and, additionally, to evaluate the feasibility of simplified analysis to measure the specific volume of distribution (V-3') using single-sample blood data because the tissue ratio (RT) may be a less reliable measure of D-2 binding in the presence of metabolites. Methods: Multilinear regression analysis (MLRA) and graphical analysis (GA) using plasma parent (P)plus metabolite (M) activities as input and time activities of receptor-free (RF, cerebellum) and receptor-containing regions (RR, striatum and temporal cortex) derived V-3' = (alpha(RR)(P) - alpha(RF)(P)), V-3' = (1 + delta) (alpha(RR) - alpha(RF)) and R-T = V-3'/ (V-2(P)' + delta V-2(M)'), where alpha is a regression coefficient, delta is the equilibrium area ratio of Mand P, and (V-2(P)'/V) are the corresponding nondisplaceable distribution volumes. V-3' by simplified analysis (SA) was calculated from R-T determined without blood data and (V-2(P)' + delta V-2(M)') with single-blood sampledata. The accuracy of these three V-3' values was assessed relative to themetabolite-accounted kinetic analysis (KA) for [I-123]epidepride SPECT studies of 11 healthy volunteers, in which each participant had 27 scans and 30 plasma samples drawn during the 14 h after injection. Results: All three V-3' values (mL/g) significantly correlated with those by KA (r greater than or equal to 0.90) (striatum/temporal cortex: MLRA, 77.8 +/- 36.6/2.35 +/-1.16; GA, 98.8 +/- 34.2/4.61 +/- 1.77; SA, 83.9 +/- 24.8/4.26 +/- 1.74; KA, 107.6 +/- 34.4/5.61 +/- 1.84). However, the correlation between R-T and V-3' was only moderate (r less than or equal to 0.65) because of significantintersubject variability (23%) in (V-2(P)' + delta V-2(M)'). Conclusion: The graphical analysis can be extended to account for metabolites in measuring D-2 binding with [I-123]epidepride SPECT for both high and low D-2 density regions. Additionally, simplified V-3' measurements with single blood sampling are feasible and may be a practical alternative to the tissue ratio R-T because R-T suffers as a measure of D-2 binding from significant intersubject variability in the metabolite-contributed distribution volume of thenondisplaceable compartment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/12/19 alle ore 12:04:24