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Titolo:
Assessment of the reproducibility of baseline and hyperemic myocardial blood flow measurements with O-15-labeled water and PET
Autore:
Kaufmann, PA; Gnecchi-Ruscone, T; Yap, JT; Rimoldi, O; Camici, PG;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Sch Med, Cyclotron Unit,MRC, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med London England W12 0NN gland
Titolo Testata:
JOURNAL OF NUCLEAR MEDICINE
fascicolo: 11, volume: 40, anno: 1999,
pagine: 1848 - 1856
SICI:
0161-5505(199911)40:11<1848:AOTROB>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CORONARY-ARTERY DISEASE; SPATIAL HETEROGENEITY; PERFUSION RESERVE; N-13 AMMONIA; DOG HEARTS; HEMODYNAMICS; MICROSPHERES; ANGIOPLASTY; DEPENDENCE;
Keywords:
coronary circulation; myocardial blood flow; adenosine; O-15-labeled water; PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Camici, PG Univ London Imperial Coll Sci Technol & Med, Hammersmith Hosp, Sch Med, Cyclotron Unit,MRC, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med London England W12 0NN
Citazione:
P.A. Kaufmann et al., "Assessment of the reproducibility of baseline and hyperemic myocardial blood flow measurements with O-15-labeled water and PET", J NUCL MED, 40(11), 1999, pp. 1848-1856

Abstract

PET with O-15-labeled water allows noninvasive quantification of myocardial blood flow (MBF) at baseline and during pharmacologically induced hyperemia to assess the coronary vasodilator reserve (CVR = hyperemic/baseline MBF). Despite widespread use of PET, its reproducibility during one study session has not been tested. Intravenous adenosine (Ado), a powerful coronary vasodilator with a very short decay time, is commonly used for the inductionof hyperemia. However, it is not known whether Ado can induce tachyphylaxis after short-term repetitive administration. In this study, we aimed to test the reproducibility of PET assessment of CVR during Ado-induced hyperemia. Methods: In 21 healthy volunteer men, baseline and Ado MBF were measuredtwice using PET with O-15-labeled water to obtain two CVR assessments within 1 h. Results: There was no significant difference between the two baselines (0.89 +/- 0.14 versus 0.99 +/- 0.15 mL/min/g, mean difference 13% +/- 11%) or between the two hyperemic MBFs (3.51 +/- 0.45 versus 3.83 +/- 0.49 mL/min/g, mean difference 10% +/- 14%), resulting in comparable values of CVR (4.05 +/- 0.75 versus 3.93 +/- 0.72, mean difference 2% +/- 15%), The repeatability coefficient for MBF was 0.17 mL/min/g at baseline and 0.94 mL/min/g during hyperemia. The repeatability coefficient of the rate pressure product (RPP) was lower at baseline (1,304 mm Hg x beat/min) than during hyperemia (3,448 mm Hg x beat/min). Conclusion: Repeated measurements of MBF and CVR during the same study session were not significantly different, demonstrating the validity of the technique. The larger variability of hyperemicflow, as indicated by the larger repeatability coefficient, was paralleledby a greater variability of the RPP. This could mean that the greater variability of MBF during stress is more likely due to a variable response to Ado rather than to a measurement error.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 20:04:47