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Titolo:
Altered midline axon pathways and ectopic neurons in the developing hypothalamus of netrin-1-and DCC-deficient mice
Autore:
Deiner, MS; Sretavan, DW;
Indirizzi:
Univ Calif San Francisco, Dept Ophthalmol, Beckman Vis Ctr, Program BiomedSci, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CAUSA 94143 ancisco, CA 94143 USA Univ Calif San Francisco, Dept Physiol, Beckman Vis Ctr, Program Biomed Sci, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 22, volume: 19, anno: 1999,
pagine: 9900 - 9912
SICI:
0270-6474(19991115)19:22<9900:AMAPAE>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE OPTIC CHIASM; NERVE HYPOPLASIA; MEDIAN-EMINENCE; GROWTH; GENE; CELLS; PITUITARY; GUIDANCE; REQUIRES; PROTEIN;
Keywords:
optic chiasm; netrin; DCC; hypothalamus; gonadotropin-releasing hormone; luteinizing hormone-releasing hormone; antidiuretic hormone; vasopressin; supraoptic nucleus; oxytocin; visual system; retinal ganglion cell; axon guidance; cell migration; diencephalon; CD44; organum vasculosum of the lamina terminalis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Sretavan, DW Univ Calif San Francisco, Dept Ophthalmol, Beckman Vis Ctr, Program BiomedSci, 10 Kirkham St,Room K107, San Francisco, CA 94143 USA UnivCalif San Francisco 10 Kirkham St,Room K107 San Francisco CA USA 94143
Citazione:
M.S. Deiner e D.W. Sretavan, "Altered midline axon pathways and ectopic neurons in the developing hypothalamus of netrin-1-and DCC-deficient mice", J NEUROSC, 19(22), 1999, pp. 9900-9912

Abstract

Optic nerve formation in mouse involves interactions between netrin-1 at the optic disk and the netrin-1 receptor DCC (deleted in colorectal cancer) expressed on retinal ganglion cell (RGC) axons. Deficiency in either protein causes RGC pathfinding defects at the disk leading to optic nerve hypoplasia (Deiner et al., 1997). Here we show that further along the visual pathway, RGC axons in netrin-1- or DCC-deficient mice grow in unusually angular trajectories within the ventral hypothalamus. In heterozygous Sey(neu) micethat also have a small optic nerve, RGC axon trajectories appear normal, indicating that the altered RGC axon trajectories in netrin-1 and DCC mutants are not secondarily caused by optic nerve hypoplasia. Intrinsic hypothalamic patterning is also affected in netrin-1 and DCC mutants, including a severe reduction in the posterior axon projections of gonadotropin-releasing hormone neurons. In addition to axon pathway defects, antidiuretic hormone and oxytocin neurons are found ectopically in the ventromedial hypothalamus, apparently no longer confined to the supraoptic nucleus in mutants. In summary, netrin-1 and DCC, presumably via direct interactions, govern both axon pathway formation and neuronal position during hypothalamic development,and loss of netrin-1 or DCC function affects both visual and neuroendocrine systems. Netrin protein localization also indicates that unlike in more caudal CNS, guidance about the hypothalamic ventral midline does not requiremidline expression of netrin.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 20:32:16