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Titolo:
Enhanced amygdala kindling after electrical stimulation of the ventral tegmental area: Implications for fear and anxiety
Autore:
Gelowitz, DL; Kokkinidis, L;
Indirizzi:
Univ Canterbury, Dept Psychol, Christchurch 1, New Zealand Univ Canterbury Christchurch New Zealand 1 , Christchurch 1, New Zealand Univ Cincinnati, Med Ctr, Dept Psychiat, Cincinnati, OH 45267 USA Univ Cincinnati Cincinnati OH USA 45267 sychiat, Cincinnati, OH 45267 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 22, volume: 19, anno: 1999,
pagine: NIL_17 - NIL_21
SICI:
0270-6474(19991115)19:22<NIL_17:EAKAES>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
COCAINE-INDUCED PARANOIA; POTENTIATED STARTLE; SUBSTANTIA-NIGRA; AMPHETAMINE SENSITIZATION; CONDITIONED STRESS; ACOUSTIC STARTLE; DOPAMINE NEURONS; SEIZURE ACTIVITY; EXPRESSION; MODEL;
Keywords:
ventral tegmental area; central amygdala; neural discharge; electrical stimulation; kindling; sensitization; fear and anxiety;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Kokkinidis, L Univ Canterbury, Dept Psychol, Private Bag 4800, Christchurch 1, New Zealand Univ Canterbury Private Bag 4800 Christchurch New Zealand1
Citazione:
D.L. Gelowitz e L. Kokkinidis, "Enhanced amygdala kindling after electrical stimulation of the ventral tegmental area: Implications for fear and anxiety", J NEUROSC, 19(22), 1999, pp. NIL_17-NIL_21

Abstract

Electrical kindling refers to the seizure-generating properties of brain stimulation. In addition to producing epilepsy, the reorganization of forebrain neurocircuitry associated with kindling contributes to psychiatric disturbances involving fear and anxiety. The amygdala is a limbic structure that kindles readily and regulates the complex neurocircuitry underlying emotional responding. Dopamine-containing ventral tegmental area (VTA) neurons, known to be activated by threatening environmental stimuli, are an important component of the amygdala-based fear network. Using amygdala kindling as an indicator of sensitization development, we report here that repeated low-current, high-frequency stimulation of the VTA provoked afterdischarge in the central amygdala and enhanced kindling rate. By establishing a fundamental link between VTA activation and neural excitability in the central amygdala, the present results are consistent with the possibility of a common process underlying epileptogenisis and the fear motivational consequences ofamygdala and VTA kindling. Considering the established role of the VTA andthe amygdala in emotional responding, such a sensitization mechanism mightmediate exaggerated fearfulness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:43:42