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Titolo:
ATP receptors and giant cell formation
Autore:
Di Virgilio, F; Falzoni, S; Chiozzi, P; Sanz, JM; Ferrari, D; Buell, CN;
Indirizzi:
Univ Ferrara, Dept Expt & Diagnost Med, Sect Gen Pathol, I-44100 Ferrara, Italy Univ Ferrara Ferrara Italy I-44100 ct Gen Pathol, I-44100 Ferrara, Italy Univ Ferrara, Ctr Biotechnol, I-44100 Ferrara, Italy Univ Ferrara Ferrara Italy I-44100 tr Biotechnol, I-44100 Ferrara, Italy Serono Pharmaceut Res Inst, Geneva, Switzerland Serono Pharmaceut Res Inst Geneva Switzerland Inst, Geneva, Switzerland
Titolo Testata:
JOURNAL OF LEUKOCYTE BIOLOGY
fascicolo: 5, volume: 66, anno: 1999,
pagine: 723 - 726
SICI:
0741-5400(199911)66:5<723:ARAGCF>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN P2X(7) RECEPTOR; EXTRACELLULAR ATP; MACROPHAGE MULTINUCLEATION; P-2Z RECEPTOR; EXPRESSION; CULTURES; FUSION; PORE;
Keywords:
P2 purinergic receptor; chronic inflammation; granuloma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Di Virgilio, F Univ Ferrara, Dept Expt & Diagnost Med, Sect Gen Pathol, Via Borsari 46, I-44100 Ferrara, Italy Univ Ferrara Via Borsari 46 Ferrara Italy I-44100 a, Italy
Citazione:
F. Di Virgilio et al., "ATP receptors and giant cell formation", J LEUK BIOL, 66(5), 1999, pp. 723-726

Abstract

We have investigated the role of the purinergic P2X(7) receptor in the formation of multinucleated giant cells in human monocyte/macrophage cultures stimulated with either concanavalin A or phytohemagglutinin. Macrophage fusion can be blocked by a P2X(7)-selective pharmacological antagonist or by amAb directed against the extracellular P2X(7) domain, Furthermore, macrophage cell, clones expressing high P2X(7) levels spontaneously fuse in culture, whereas macrophage clones lacking P2X(7) are unable to fuse, Our findings suggest that the newly identified purinergic P2X(7) receptor plays a central role in the complex chain of events leading to generation of macrophage-derived giant cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 09:59:23