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Titolo:
Borna disease virus in human brains with a rare form of hippocampal degeneration but not in brains of patients with common neuropsychiatric disorders
Autore:
Czygan, M; Hallensleben, W; Hofer, M; Pollak, S; Sauder, C; Bilzer, T; Blumcke, I; Riederer, P; Bogerts, B; Falkai, P; Schwarz, MJ; Masliah, E; Staeheli, P; Hufert, FT; Lieb, K;
Indirizzi:
Univ Freiberg, Dept Virol, Abt Virol, Inst Med Mikrobiol & Hyg, D-79104 Freiberg, Germany Univ Freiberg Freiberg Germany D-79104 & Hyg, D-79104 Freiberg, Germany Univ Freiberg, Abt Psychiat, D-79104 Freiberg, Germany Univ Freiberg Freiberg Germany D-79104 ychiat, D-79104 Freiberg, Germany Univ Freiberg, Inst Rechts Med, D-79104 Freiberg, Germany Univ Freiberg Freiberg Germany D-79104 ts Med, D-79104 Freiberg, Germany Univ Dusseldorf, Inst Neuropathol, D-4000 Dusseldorf, Germany Univ Dusseldorf Dusseldorf Germany D-4000 ol, D-4000 Dusseldorf, Germany Univ Bonn, Zentrum Nervenheilkunde, D-5300 Bonn, Germany Univ Bonn Bonn Germany D-5300 trum Nervenheilkunde, D-5300 Bonn, Germany Univ Wurzburg, Klin Neurochem, Abt Psychiat, Wurzburg, Germany Univ Wurzburg Wurzburg Germany urochem, Abt Psychiat, Wurzburg, Germany Univ Magdeburg, Abt Psychiat, D-39106 Magdeburg, Germany Univ Magdeburg Magdeburg Germany D-39106 iat, D-39106 Magdeburg, Germany Univ Munich, Abt Psychiat, Munich, Germany Univ Munich Munich GermanyUniv Munich, Abt Psychiat, Munich, Germany Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA Univ Calif SanDiego La Jolla CA USA 92093 urosci, La Jolla, CA 92093 USA
Titolo Testata:
JOURNAL OF INFECTIOUS DISEASES
fascicolo: 5, volume: 180, anno: 1999,
pagine: 1695 - 1699
SICI:
0022-1899(199911)180:5<1695:BDVIHB>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD MONONUCLEAR-CELLS; SEQUENCE CONSERVATION; PSYCHIATRIC-PATIENTS; BIPOLAR DISORDER; BDV RNA; SCHIZOPHRENIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Staeheli, P Univ Freiberg, Dept Virol, Abt Virol, Inst Med Mikrobiol & Hyg, Hermann Herder Str 11, D-79104 Freiberg, Germany Univ Freiberg Hermann Herder Str 11 Freiberg Germany D-79104
Citazione:
M. Czygan et al., "Borna disease virus in human brains with a rare form of hippocampal degeneration but not in brains of patients with common neuropsychiatric disorders", J INFEC DIS, 180(5), 1999, pp. 1695-1699

Abstract

To estimate the frequency of persistent Borna disease virus (BDV) infections of the human central nervous system and to determine which neuropsychiatric disorders might be associated with this viral infection, reverse transcription-nested polymerase chain reaction was used to screen a large collection of autopsy brain samples for the presence of BDV-specific nucleic acids. The presence of BDV RNA was found in 3 brains of persons with psychiatricsymptoms and prominent hippocampal degeneration previously reported to be positive by others. However, no BDV RNA was detected in 86 randomly collected brains from persons with various psychiatric disorders, including schizophrenia, affective disorders, and Alzheimer's disease, or from suicide victims or in 52 brains from healthy controls. Furthermore, no BDV-RNA was detected in 16 surgical brain samples from persons with epilepsy-associated hippocampal sclerosis, These results indicate that life-long persistent BDV infections are rare in humans and that such infections may be associated withcertain forms of hippocampal degeneration.

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Documento generato il 26/01/20 alle ore 16:02:16