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Titolo:
Variants of the human NRAMP1 gene and altered human immunodeficiency virusinfection susceptibility
Autore:
Marquet, S; Sanchez, FO; Arias, M; Rodriguez, J; Paris, SC; Skamene, E; Schurr, E; Garcia, LF;
Indirizzi:
McGill Univ, Montreal Gen Hosp, Res Inst,Dept Med Biochem, McGill Ctr Study Host Resistance, Montreal, PQ H3G 1A4, Canada McGill Univ Montreal PQ Canada H3G 1A4 ance, Montreal, PQ H3G 1A4, Canada Univ Antioquia, Grp Immunol Celular & Immunogenet, Fac Med, Medellin, Colombia Univ Antioquia Medellin Colombia munogenet, Fac Med, Medellin, Colombia
Titolo Testata:
JOURNAL OF INFECTIOUS DISEASES
fascicolo: 5, volume: 180, anno: 1999,
pagine: 1521 - 1525
SICI:
0022-1899(199911)180:5<1521:VOTHNG>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
MANNOSE-BINDING LECTIN; NATURAL-RESISTANCE; MACROPHAGE PROTEIN; HIV-INFECTION; PROGRESSION; DISEASE; IDENTIFICATION; TUBERCULOSIS; EXPRESSION; CANDIDATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Schurr, E McGill Univ, Montreal Gen Hosp, Res Inst,Dept Med Biochem, McGill Ctr Study Host Resistance, L11-521,1650 Cedar Ave, Montreal, PQ H3G 1A4, Canada McGill Univ L11-521,1650 Cedar Ave Montreal PQ Canada H3G 1A4 da
Citazione:
S. Marquet et al., "Variants of the human NRAMP1 gene and altered human immunodeficiency virusinfection susceptibility", J INFEC DIS, 180(5), 1999, pp. 1521-1525

Abstract

In a population-based case-control study, 182 human immunodeficiency virus(HIV)-positive persons and 135 healthy control subjects were enrolled fromthe metropolitan area of Medellin, Colombia, Four genotypes of the naturalresistance-associated macrophage protein 1 (NRAMP1) gene (5' GT repeat, 274C/T, 469+14G/T, and 823C/T) were associated with altered risk of HIV infection (P =.013, .015, .020, and .035, respectively). Three of these markers (5' [GT](n), 274C/T, 469+14G/T) are in strong linkage disequilibrium, and genotypes of these markers are associated with reduced risk of HIV infectionwith relative risks (RRs) of 0.35 (95% confidence interval [CI], 0.14-0.91), 0.31 (CI, 0.10-0.93), and 0.24 (CI, 0.08-0.72), respectively. Conversely, heterozygosity at the fourth independent marker (823C/T) was associated with increased risk of HIV infection (RR, 2.29; CI, 1.06-4.92), These findings suggest that NRAMP1 modifies risk of HIV infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 15:01:40