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Titolo:
Seroreactivity to human papillomavirus types 16, 18, 31, and 45 virus-likeparticles in a case-control study of cervical squamous intraepithelial lesions
Autore:
Wideroff, L; Schiffman, M; Haderer, P; Armstrong, A; Greer, CE; Manos, MM; Burk, RD; Scott, DR; Sherman, ME; Schiller, JT; Hoover, RN; Tarone, RE; Kirnbauer, R;
Indirizzi:
NCI, Epidemiol & Biostat Program, Div Canc Epidemiol & Genet, Bethesda, MD20892 USA NCI Bethesda MD USA 20892 v Canc Epidemiol & Genet, Bethesda, MD20892 USA NCI, Cellular Oncol Lab, Bethesda, MD 20892 USA NCI Bethesda MD USA 20892NCI, Cellular Oncol Lab, Bethesda, MD 20892 USA Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA Johns HopkinsMed Inst Baltimore MD USA 21205 ol, Baltimore, MD 21205 USA Univ Vienna, Sch Med, Dept Dermatol, Div Immunol Allergy & Infect Dis, A-1010 Vienna, Austria Univ Vienna Vienna Austria A-1010 y & Infect Dis, A-1010 Vienna, Austria Kaiser Permanente Ctr Hlth Res, Portland, OR USA Kaiser Permanente Ctr Hlth Res Portland OR USA lth Res, Portland, OR USA Cetus Corp, Emeryville, CA 94608 USA Cetus Corp Emeryville CA USA 94608Cetus Corp, Emeryville, CA 94608 USA Albert Einstein Coll Med, Bronx, NY 10467 USA Albert Einstein Coll Med Bronx NY USA 10467 Coll Med, Bronx, NY 10467 USA
Titolo Testata:
JOURNAL OF INFECTIOUS DISEASES
fascicolo: 5, volume: 180, anno: 1999,
pagine: 1424 - 1428
SICI:
0022-1899(199911)180:5<1424:STHPT1>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOGLOBULIN-G RESPONSES; SERUM ANTIBODIES; RISK FACTOR; WOMEN; CANCER; INFECTION; NEOPLASIA; DYSPLASIA; COHORT; DNA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Wideroff, L NCI, ARB, EPN 313, MSC 7344, 6130 Execut Blvd, Bethesda, MD 20892 USA NCI 6130 Execut Blvd Bethesda MD USA 20892 hesda, MD 20892 USA
Citazione:
L. Wideroff et al., "Seroreactivity to human papillomavirus types 16, 18, 31, and 45 virus-likeparticles in a case-control study of cervical squamous intraepithelial lesions", J INFEC DIS, 180(5), 1999, pp. 1424-1428

Abstract

Serum IgG antibodies to human papillomavirus (HPV) types 16, 18, 31, and 45 virus-like particles were measured in a nested case-control study of cervical squamous intraepithelial lesions. HPV-16 seroreactivity was strongly associated with HPV-16 DNA detection (odds ratio, 9.0; 95% confidence interval, 4.4-19.4), and similar type specificity was observed for HPV-31 and -45. In contrast, seroreactivity to any type was associated with elevated seroreactivity to all others. Among cases and controls, HPV-16 showed the highest seroprevalence, with 23.8% of 80 cases and 10.5% of 258 controls seroreactive to HPV-16 alone, and another 27.5% and 5.4%, respectively, seroreactive to HPV-16 plus other types. Overall, 24 (30.0%) cases and 17 (6.6%) controls were seroreactive to multiple types. These data suggest that seroreactivity to a given type reflects mainly type-specific HPV infection as measured by DNA detection and may also signal past exposure to other types that are now only serologically detected.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 07:33:28